Abstract
Acute Lymphoblastic Leukemia (ALL) is the most common type of cancer in children. It is known that the interaction of leukemic blast cells with their microenvironment increases ALL resistance to chemotherapy. In recent work, we have shown the increased expression and secretion of IGFBP7 in leukemic cells after co-culture with bone marrow stroma cells. The 'leukemic' IGFBP7 together with I…