CV Lattes
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Ministério da Ciência, Tecnologia e Inovação (Brasil). Centro Nacional de Pesquisa em Energia e Materiais (CNPEM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Biological Sciences at the State University of Campinas (UNICAMP), PhD in Functional and Molecular Biology at UNICAMP with an internship at MD Anderson Cancer Center (Houston, USA) and postdoctoral fellow in Developmental Biology and Genome Editing at LNBio/ CNPEM. She is currently a Lead Researcher at the Brazilian Biosciences National Laboratory (LNBio/CNPEM), coordinating the Genetically Modified Systems Group (SGM), the Genome Editing Laboratory (LEG) and the Animal Management and Experimentation Laboratory (LMEA). She works on Genome Editing (CRISPR/Cas9, Base Editing, Prime Editing technologies) applied to the study of molecular mechanisms of human diseases and production of new advanced therapies (gene therapy) for the treatment of human diseases. She has experience in Molecular and Cellular Biology, Genetics, Biochemistry, Genome Editing in animal and cellular models, and gene therapy. (Source: Lattes Curriculum)
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The activity of enzymes in the protein ubiquitination pathway is critical for synaptic development and function, as well as for mitochondrial and cellular homeostasis, and dysregulation of these enzymes has been increasingly associated with neurodevelopmental and neurodegenerative diseases. Intellectual Disability (ID) is characterized by cognitive limitations and deficits in adaptive beh…
Mucopolysaccharidosis type I (MPS I) is a monogenic disease, with autosomal recessive inheritance, caused by mutations in the IDUA gene. These mutations result in the absence or deficiency of activity of the lysosomal enzyme alpha-L-Iduronidase (IDUA), necessary for the degradation of iduronic acid residues of glycosaminoglycans. The severe form of MPS I is known as Hurler Syndrome (MPS I…
Neurodegenerative diseases affect millions of people worldwide and there are still no therapies able to reduce the progression of the disease and causing few adverse effects. UCH-L1 is a deubiquitinase enzyme fundamental for ubiquitin level maintenance, regulation of specific protein degradation, and cellular redox state. It is highly expressed in neurons, and in neurodegenerative disease…
Ubiquitin-conjugating enzymes (E2) are key components in the protein ubiquitination pathway which, in addition to signaling substrates for degradation, can also regulate other cellular processes. UBE2A is an E2 of this pathway and has been reported to act in several processes, such as DNA repair, maintenance of genomic integrity, regulation of p53 expression, removal of dysfunctional mito…
Ubiquitination is a post-translational modification involved in many cellular processes, like mitophagy, DNA-damage repair, protein degradation by the ubiquitin-proteasome system, and synaptic transmission. UBE2A, an ubiquitin-conjugating enzyme (E2), may perform these described functions by interacting with other proteins, such as E3 ligases RAD18 and Parkin. Due to cellular functions de…
The CRISPR/Cas9 technology has recently emerged as an effective alternative for the introduction of site-specific modifications into the genome. Compared to the previously techniques, CRISPR/Cas9 has lower cost, greater efficiency and speed to edit the genome in multiple cell types and organisms. The CRISPR/Cas9 system is based on the use of a small RNA which is able to pair with target D…
(Only some records are available in English at this moment)
UBE2A is an ubiquitin-conjugating enzyme key component of the ubiquitination pathway and has been reported to act in several processes, such as DNA repair, maintenance of genomic integrity, regulation of p53 expression, removal of dysfunctional mitochondria and regulation of proteasome activity. The Q93E mutation in UBE2A, found in Brazilian patients, can directly interfere with its activ…
Ki-1/57 is a regulatory protein, intrinsically unstructured, located in the nucleus and cytoplasm. It is encoded by the gene Habp4, located on chromosome 13 in mice. Several post-translational modifications regulate the function of Ki-1/57 such as phosphorylation by PKC, methylation by PRMT1 and SUMOylation. Yeast Two-hybrid assays and immunoprecipitation from mammalian cells extracts sho…
| 1 / 1 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 5 / 4 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 11 / 10 | All research grants and scholarships |
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