Stela Virgilio

• Abstract

  Considering that DNA damage is an important modulator of chromatin states, our aim is not only to evaluate the existence of genomic sites of recurrent replication stress or DNA damage, but also characterize the chromatin environment associated to these sites in Trypanosoma cruzi and Leishmania major. (AU)

  Defining the epigenetic landscape in Trypanosoma Cruzi and Leishmania major cells subjected to DNA injury, BP.PD

• Abstract

  In this project we propose the identification of sites of conflict between the processes of replication and transcription in trypanosomatids using a non-targeted approach. We will use chromatin immunoprecipitation of proteins that bind to DNA structures related to replication stress and/or resolution of the replication-transcription clash. The use of high-throughput sequencing will allow …

  Characterizing stress response of DNA replication in the protozoan Leishmania: the case of replication-transcription conflict, BP.PD

• Abstract

  The work presented here is part of a thematic project that aims to study the biochemical and molecular mechanisms involved in the regulation of glycogen metabolism using as model the fungus Neurospora crassa. Recently, a collection of mutant strains containing genes that encode transcription factors individually knocked-out was acquired by the laboratory. A screening was performed as an a…

  Correlation between biological clock and glycogen metabolism in Neurospora crassa. Functional analysis of proteins/transcription factors involved in these processes., BP.DR

(Only some records are available in English at this moment)

• Abstract

  Metabolism of storage carbohydrate, such as glycogen, is under regulation of the circadian clock in mammals, and dysfunction of either glucose metabolism or clock regulation is associated with insulin resistance and diabetes. Glycogen is synthesized and degraded as a function of the organism metabolism status and the endogenous clock determines properties of this regulation. Regulation of…

  Connection studies between biological clock and glycogen metabolism regulation in Neurospora crassa, BE.EP.DR