Defining the epigenetic landscape in Trypanosoma Cruzi and Leishmania major cells subjected to DNA injury

• Grant number: 19/25769-1
• Support type: Scholarships in Brazil - Post-Doctorate
• Effective date (Start): February 01, 2020
• Effective date (End): March 31, 2021
• Field of knowledge: Biological Sciences - Parasitology - Protozoology of Parasites
• Cooperation agreement: MRC, UKRI ; Newton Fund, with FAPESP as a partner institution in Brazil
• Principal Investigator: Luiz Ricardo Orsini Tosi
• Grantee: Stela Virgilio
• Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant: 18/14432-3 - A network for an integrative biology in neglected diseases: bridging epigenetics, metabolism and cell cycle in pathogenic trypanosomatids, AP.TEM

Abstract

Considering that DNA damage is an important modulator of chromatin states, our aim is not only to evaluate the existence of genomic sites of recurrent replication stress or DNA damage, but also characterize the chromatin environment associated to these sites in Trypanosoma cruzi and Leishmania major. (AU)