Abstract
Hypoxia is a known adverse factor in cancer treatment, able to activate signaling pathways MAPK and PI3K / Akt / mTOR, the two major pathways involved in the process of angiogenesis which is regulated by numerous factors, the most significant is the Hypoxia-Inducible Factor - 1 (HIF-1) and Vascular Endothelial Growth Factor (VEGF). The transcription factor HIF-1± is the major regulator of…