André Uchimura Bastos
CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduation at Licenciatura Plena em Ciências Biológicas from Centro Universitário Fundação Santo André (2009), graduation at Ciências Biológicas from Centro Universitário Fundação Santo André (2010) and doctorate at Biologia Estrutural e Funcional from Universidade Federal de São Paulo (2016). Has experience in Genetics, focusing on Human and Medical Genetics, acting on the following subjects: rearranjos ret/ptc, carcinoma papilífero da tiróide, braf, men2a and medullary thyroid carcinoma. (Source: Lattes Curriculum)
- Resistance mechanisms to treatment with temozolomide in glioma cells, BP.PD
Abstract
Patients with glioblastoma, the most common type of malignant neoplasm of the brain in adults, still show poor prognoses with the available therapeutic protocols, and Temozolomide (TMZ) is the main drug used to treat this type of tumor. TMZ is an alkylating agent that causes DNA methylation and a wide range of DNA damage (genomic and mitochondrial), leading to cell death. However, tumor...
- Functional characterization of BRAFV600E + RET/PTC3 double mutation in papillary thyroid carcinoma, BP.DD
Abstract
The Papillary Thyroid Carcinoma (PTC) is the most common histological subtype of thyroid tumors. Alterations in genes coding for the MAPK pathway plays a crucial role in its pathogenesis, and mutations in the BRAF and RAS oncogenes and rearrangements involving the RET oncogene are the most frequent. The recognition of these alterations and the association studies can lead to the most ef...
- RET/PTC rearrangements: prevalence, clinical-pathologic correlation and gene expression profile in patients with papillary thyroid carcinoma, BP.MS
- Alkylation and redox induced DNA lesions in glioma cells damaged by temozolomide, BE.EP.PD
Abstract
Temozolomide (TMZ) is the main drug used to treat gliomas, which causes DNA damage leading to cell death mainly as a consequence of processing of the primary damage O6-methylguanine (O6meG). Several mechanisms of resistance were described, and the ability of MGMT (O-6-methylguanine-DNA methyltransferase) to directly reverse O6meG in the DNA molecule is the most significant. Moreover, th...
- Functional characterization of BRAFV600E and RET/PTC double mutation and methylation profiling in in vitro model and thyroid tumors, BE.EP.DD
Abstract
Genetic alterations play a crucial role in pathogenesis, diagnosis and treatment of thyroid tumors. The Papillary Thyroid Carcinoma is the most prevalent subtype, and mutations in BRAF and RAS oncogenes and rearrangements involving the RET oncogene are the most frequent. Our group investigated the prevalence of RET/PTC rearrangements and BRAF V600E mutation in a series of CPT (n = 118) ...
| 3 / 3 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 1 / 1 | Completed scholarships abroad |
| 5 / 5 | All Scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 2 |
| Citations | 9 |
| Cit./Article | 4.5 |
| Data from Web of Science | |
DE JESUS PANIZA, ANA CAROLINA; MENDES, THAIS BIUDE; BORGES VIANNA, MATHEUS DUARTE; DIAS THOMAZ, DEBORA MOTA; CHIAPPINI, PAULA B. O.; COLAZZA-GAMA, GABRIEL A.; LINDSEY, SUSAN CHOW; DE CARVALHO, MARCOS BRASILINO; FERREIRA ALVES, VENANCIO AVANCINI; CURIONI, OTAVIO; et al. Revised criteria for diagnosis of NIFTP reveals a better correlation with tumor biological behavior. ENDOCRINE CONNECTIONS, v. 8, n. 11, p. 1529-1538, NOV 2019. Web of Science Citations: 0. (17/06487-0, 14/06570-6, 16/25784-2, 17/16315-1)
BASTOS, ANDRE UCHIMURA; DE JESUS, ANA CAROLINA; CERUTTI, JANETE MARIA. ETV6-NTRK3 and STRN-ALK kinase fusions are recurrent events in papillary thyroid cancer of adult population. EUROPEAN JOURNAL OF ENDOCRINOLOGY, v. 178, n. 1, p. 83-91, JAN 2018. Web of Science Citations: 9. (12/06221-6, 13/03867-5)