Graduated in Marine Sciences from Universidade do Porto, Portugal (1993) and Ph.D. in Biochemistry from Universidade de São Paulo (2000). Visiting Scientist at Cold Spring Harbor Laboratory, NY- EUA from 08/2008 to 02/2010. Research areas in Molecular Biology and Genomics, focusing on large-scale analysis of gene expression, molecular markers of cancer, noncoding RNAs. (Source: Lattes Curriculum)
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Pancreatic cancer is one of the most lethal neoplasms and only 5% of affected individuals survive more than 5 years after diagnosis, with ductal adenocarcinoma (PDAC) being the most prevalent and aggressive type. Chemotherapy with gemcitabine is the standard treatment protocol for invasive PDAC and is also used as adjuvant therapy after surgical removal of the tumor. However, the clinical…
The three aims in this proposal are (1) to determine novel long noncoding RNAs expressed in pancreatic cancer using RNA-seq data, (2) to detect somatic mutations in noncoding regions and to identify significantly mutated noncoding genes using WGS data from TCGA, (3) to determine cases where somatic mutations in noncoding RNA regions disrupted the expression of neighboring genes. The plann…
Pancreatic cancer is one of the most lethal neoplasms and only 5% of affected individuals survive for more than five years after diagnosis. This is due to limitations to detect the disease in early stages and to the absence of effective therapeutic options. Ductal adenocarcinoma (PDAC) is the most prevalent pancreatic neoplasia, extremely aggressive and the only curative treatment availab…
(Only some records are available in English at this moment)
This project aims to investigate the contribution of long non-coding RNAs (lncRNAs) to epigenetic reprogramming and control of gene expression in Pancreatic Ductal Adenocarcinoma (PDAC). The hypothesis that motivates this study is that lncRNAs can interact with components of the epigenetic machinery, directing it to specific loci in order to modify chromatin activation/repression states, …
The project aims to generate immortalized PDAC cell lines resistant to gemcitabine, and the molecular characterization of this resistance. Such lines will be generated by prolonged treatments under sub-lethal concentrations of the drug and will have their resistance evaluated by determining the expression of resistance marker genes already described in the literature by RT-qPCR. In additi…
Aging related diseases are the leading cause of death in the world. This study aims to investigate molecular aspects of innate immunity in the senescence process, and as a predisposition factor for the development of sepsis, a complex disease associated with aging. We will perform a broad gene expression analysis to identify genes with a critical role in the aging process and to investiga…
Pancreatic ductal adenocarcinoma (PDAC), the most prevalent type of pancreatic cancer, is an extremely aggressive and often lethal malignancy. The absence of effective therapeutic options motivates the search for molecular vulnerabilities in these tumors that may be explored for developing novel therapies for PDAC. In this study, we will search for essential genes to PDAC survival using a…
(Only some records are available in English at this moment)
Recent studies have shown that most of the eukaryotic genome is transcribed as noncoding RNAs (ncRNAs). Although it is clear that different classes of ncRNAs play fundamental roles in the control of gene expression, only a small fraction of the noncoding fraction of the transcriptome has been functionally characterized. This research proposal will employ molecular and cellular biology app…
| 1 / 1 | Ongoing research grants |
| 9 / 6 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 16 / 8 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 28 / 17 | All research grants and scholarships |
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CV Lattes
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