Abstract
Hydrogen peroxide and other peroxides are involved in cell signaling and therefore their levels are regulated in a quite sophisticated way. Among the various cellular systems capable of decomposing peroxides, 2-Cys peroxiredoxins (2-Cys Prx), which are peroxidases, utilize a highly reactive cysteine residue (peroxidase cysteine - CysP) to efficiently reduce a wide variety of hydroperoxide…