CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Educação Física from Universidade Paulista (2007), master's at Fitness from Universidade Estadual Paulista Júlio de Mesquita Filho (2010) and doctorate at Fitness from Universidade Estadual Paulista Júlio de Mesquita Filho (2013). Has experience in Physiology, acting on the following subjects: polimorfismo, pressao arterial, exercício físico aeróbio, dislipidemia and atividade física. (Source: Lattes Curriculum)
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Gene perturbation experiments (deletion or overexpression) are the best approach to study gene function. However, systematic perturbation experiments involving a large number of genes are generally prohibitive due to experimental limitations and ethical concerns. The application of single-cell technologies in gene perturbation experiments allows for the determination of a gene's functiona…
Brown adipose tissue (BAT) plays a fundamental role in adaptive thermogenesis, increasing whole-body energy expenditure through the activity of the UCP-1 protein. Previous studies suggest that BAT activation may contribute to improved energy homeostasis, representing a promising approach for the treatment of obesity and associated metabolic disorders. In silico analyses conducted by the r…
Brown and beige adipocytes play a crucial role in regulating energy metabolism in mammals by dissipating energy in the form of heat through thermogenesis. While brown adipocytes are established during the prenatal period, beige adipocytes are induced postnatally in response to stimuli such as cold exposure and pharmacological agents. The formation of beige adipocytes is described by two m…
Thermogenic adipocytes (brown and beige) are known for their ability to dissipate energy in the form of heat, a process known as thermogenesis. Furthermore, current studies show that these adipocytes can counteract the deleterious metabolic effects induced by obesity, such as inflammation, mitochondrial dysfunction, oxidative stress, hypoxia, fibrosis, and de novo synthesis of ceramides t…
Brown adipose tissue (BAT) is a central effector of thermogenesis and body energy homeostasis. BAT exhibits a circadian pattern of expression of clock genes (clock genes) and of genes central to thermogenic function (eg, UCP1). Transcriptome data reveal that 8% of genes expressed in BAT show a circadian behavior (fluctuation within 24 hours), twice as high as that observed for white adipo…
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Non-shivering thermogenesis (NST) plays a crucial role in maintaining body temperature in mammals, particularly in response to cold exposure. The primary tissue responsible for NST is brown adipose tissue (BAT), which is derived from the same developmental precursor as skeletal muscle myocytes. Interestingly, brown adipocytes and skeletal myocytes share many molecular features, but the un…
Brown (BAT) and beige adipose cells have the capacity to produce heat (thermogenesis) due to substrate oxidation. This futile cycle is essentially regulated by the action of uncoupling protein 1 (UCP1), a protein located in the inner mitochondrial membrane of brown and beige adipocytes 1. The thermogenesis program is considered a valuable tool to counteract metabolic diseases such as obes…
| 3 / 3 | Ongoing scholarships in Brazil |
| 8 / 8 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 1 / 1 | Completed scholarships abroad |
| 13 / 13 | All Scholarships |
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