CV Lattes
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Universidade Federal do ABC (UFABC). Centro de Ciências Naturais e Humanas (CCNH) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Faculdade de Ciências Farmacêuticas de Ribeirão Pr from Universidade de São Paulo (1997), master's at Biochemistry from Universidade de São Paulo (1999) and doctorate at Biochemistry from Faculdade de Medicina de Ribeirão Preto (2003). Has experience in Biochemistry, focusing on Metabolism and Bioenergetics, acting on the following subjects: mitochondria, phenothiazines, cell death, oxidative stress and antioxidant activity. (Source: Lattes Curriculum)
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Cancer is one of the main causes of death in the world and it has become an important public health problem, due to its increased incidence in the population, toxicity and side effects of treatment, resistance to available therapeutic options, causing a significant impact on economic to health systems. Tumor cells exhibit molecular alterations ('the hallmarks of cancer') that provide them…
Melanoma is a tumor originated in melanocytes predisposed to the accumulation of DNA damage, resulting in genetic mutations that favor its malignancy, such as the stimulation of blood vessel growth, immune response evasion, tumor invasion and metastasis. Although potentially curable sometimes, malignant melanoma is an aggressive type of cancer, with a high mortality resistance development…
Literature data have shown that psycotropic drugs derived from phenothiazines present antitumor activity. Working with isolated rat liver mitochondria, we previously showed that phenothiazine derivatives induced the mitochondrial permeability transition associated with cytochrome c release. After, we established the cytotoxic potential of different phenothiazine derivatives and determined…
(Only some records are available in English at this moment)
Cancer is one of the leading causes of death in the world and its incidence is increasing due to several factors, including individual variations, environmental conditions, increased carcinogens exposure, among others. Melanoma is a type of cancer originating in melanocytes and is considered the most serious skin cancer due to its metastatic potential. Since tumor cells exhibit several al…
Cancer is one of the main causes of death worldwide, affecting millions of people every year. Its incidence has increased globally due to a number of factors, including an ageing population, contemporary lifestyle habits, exposure to environmental carcinogens, genetic predisposition, among others. Conservative cancer treatments involve surgical resection, chemotherapy and radiotherapy, al…
Cancer is one of the leading causes of death in the world and its incidence is continually increasing. Although the therapeutic arsenal for cancer treatment has significantly improved in recent decades, several challenges remain in this area, including the unresponsiveness of some tumor types, resistance against the currently available drugs, besides the high toxicity to normal cells. Thu…
Cancer is a worldwide occurrence disease, which is considered a public health problem since it is the leading cause of population death. In 2007, it was registered 7.9 millions of deaths caused by this disease and the expectations for the next years are an increase in this number. Data indicates that will occur at least 12 millions of deaths until the year of 2030. The costs with cancer t…
The pathogenesis of neuronal disorders has been associated to the cell death with involvement of oxidative stress. The increase in the mitochondrial free radical production, persistent changes in the mitochondrial integrity (mitochondrial permeability transition, MPT) and mitochondrial depolarization seem to play central role. In this project it will be studied the effects of three psycho…
(Only some records are available in English at this moment)
Literature data have shown that psycotropic drugs derived from phenothiazines present antitumor activity. Data from our group have evidenced relevant biological effects of phenothiazines and its analogues in mitochondria, and these effects may be related to the drug capability of inducing cell death. Among the studied phenothiazine derivatives in all models studied, thioridazine was the m…
| 10 / 9 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 14 / 9 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 27 / 21 | All research grants and scholarships |
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