Abstract
The cardiovascular manifestations, particularly aortic aneurysms are the mainly cause of morbidity and mortality in Marfan syndrome (MS) that is caused by mutations in fibrillin-1 gene. Fibrillin-1 is the main protein of elastic microfibrils. Our PhD project focuses on redox processes study associated with the processing of mutated fibrillin-1 in SM. Data obtained on our in vivo SM invest…