Hugo dos Santos

• Abstract

  Chagas disease and visceral leishmaniasis are diseases caused by protozoa of the Trypanosoma cruzi and Leishmania infantum species, respectively. They are considered neglected diseases, since they affect vulnerable populations, especially in tropical and subtropical regions, and the lack of effective and safe treatments are aggravating. The work proposal for this postdoctoral research pos…

  Biological screening, design and synthesis of new chemical entities for chemotherapy., BP.PD

• Abstract

  This PhD project aims to explore the potentiality of the Morita-Baylis-Hillman adducts as efficient building blocks for the synthesis of commercially important biologically active substances. The project is divided in two subprojects. In the first one, we intend to increase the scope for the use of a bifunctional base, recently used in our research group, as catalyst for the Morita-Baylis…

  New frontiers of the Morita-Baylis-Hillman reaction: 1) New applications of a bifunctional catalyst derived from imidazole. 2) Studies on the asymmetric synthesis of a natural high-potency sweetener, BP.DD

• Abstract

  This undergraduate research project aims at carrying out kinetic resolution of carbonates derived from Morita-Baylis-Hillman, using an enantioselective allylic hydroxylation. The chiral adducts will be employed as starting material for the synthesis of chiral 1,8-dihydronaphthyridines and dihydroquinolines (AU)

  Kinetic resolution of carbonates derived from Morita-Baylis-Hillman adducts and the use of chiral adducts in the synthesis of 1,8-dihydronaphthryridines and dihydroquinolines, BP.IC

(Only some records are available in English at this moment)