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Universidade Estadual Paulista (UNESP). Campus de Araraquara. Faculdade de Odontologia (FOAr) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Estela Sasso Cerri in research grants and scholarships supported by FAPESP.
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Background: During COVID-19 pandemic, men had reduced serum testosterone and higher mortality rate than women. Variations in high density lipoprotein (HDL) levels were detected in severe COVID-19 individuals. We evaluated the response of testicular macrophages, steroidogenic activity and lipid metabolism of Leydig cells in SARS-CoV-2-infected K18-hACE2 mice.Methods: Testes were analyzed u…
ACE2 and TMPRSS2 proteins allow the SARS-CoV-2 virus entry into the host cells, inducing Covid-19- associated respiratory distress syndrome. Besides lung cells, these proteins are also found in salivary glands, testes and epididymis. Saliva is a common medium for virus transmission, and the salivary gland is a site of viral infection, replication and transmission. Studies have demonstrat…
Depression has affected million people worldwide and the antidepressant drugs, such as selective serotonin-norepinephrine reuptake inhibitors (SNRIs), have been clinically prescribed. Male patients treated with venlafaxine, a SNRI, has demonstrated reduced serum testosterone levels and erectile and ejaculatory dysfunctions. However, studies about the effect of venlafaxine on the histophys…
(Only some records are available in English at this moment)
Epididymo-orchitis is an inflammation of the testicles and epididymis that can compromise male fertility by causing spermatogenic dysfunction, disruption of the blood-testis barrier, and reduced sperm motility. Animal models have shown that bacterial and viral infections trigger exacerbated inflammatory responses, characterized by increased pro-inflammatory cytokines and leukocyte infiltr…
The epididymis plays a crucial role in male fertility. During the passage along the epididymis, spermatozoa, newly released from the testis, acquire ability to fertilize the oocyte. This organ consists of a single highly convoluted duct divided into four main anatomical regions: the initial segment, head, body, and tail. The latter region is important for the final maturation, storage, an…
Saliva is essential for lubrication, digestion, protection against pathogens, and maintenance of acid-base balance. Diacerein, an anti-inflammatory agent that inhibits pro-inflammatory cytokines such as TNF-± and IL-1², has been clinically used in cases of osteoarthritis. The detrimental effects of diacerein on the testicular function of rodents, under normal conditions, have been reporte…
The k18-hACE2 transgenic mice that express human ACE2, an essential protein for the infection of host cell by SARS-CoV-2, has been used to investigate the impact of the viral infection. The epididymis, an essential organ for male fertility, is responsible for spermatozoa maturation and protection of these cells against pathogens. The epithelial and stromal cells exert immunological respon…
(Only some records are available in English at this moment)
The global pandemic COVID-19, caused by SARS-CoV-2, lead to millions of deaths worldwide, and studies have shown that men were more susceptible to infection. The epididymis is an essential organ for male fertility since the specialized luminal environment provides sperm motility and fertilizing capacity. Clear cells, one of the most abundant cells in the epididymis, regulate the luminal f…
Background: The research group of Dr. Hinton's laboratory has been investigating molecular mechanisms involved in the control of Wolffian duct (WD)/epididymis morphogenesis, which in turn is necessary for normal male fertility. Recently, this group has demonstrated the presence of periostin within the extracellular matrix (ECM) surrounding the developing WD and has been hypothesized to re…