Débora Cristina Hipólide

• Abstract

  Sleep deprivation (SD) for long periods has several consequences for the organism, among them the reduction of hippocampal neurogenesis (HN). Animal models show that new neurons formed in the hippocampus play an important role in cognitive functions and mood. During the process of neurogenesis the cells go through several phases, a phenomenon known as cell cycle, and the rate of progressi…

  Effects of sleep deprivation on the cell cycle of neural precursor cells: modulation by caffeine and consequences on memory, AP.R

• Abstract

  A great research interest in our studies is related to the deleterious effects of sleep loss produces, specifically cognitive functions such as memory. An interesting result obtained in our laboratory indicates that sleep deprivation (PS) in rats before aversive learning task produces animal performance impaired. Motivated by the results found and the search of the mechanisms associated w…

  Effects of sleep deprivation in adenosine signaling in the hippocampus, AP.R

• Abstract

  Among the functions assigned to sleep, stands out its participation in learning and memory processes. Studies already have shown that sleep deprivation impairs the consolidation of memories. However, the mechanisms involved in this effect have not been clarified yet. Recent data indicate the involvement of immune system components in memory impairment induced by sleep deprivation. We sugg…

  Manipulation of the cytokine network and the effects on memory impairment observed in the sleep deprivation, AP.R

(Only some records are available in English at this moment)

• Abstract

  Science communication's importance for society is being recognized more than ever. The Laboratório de Estudos Avançados em Jornalismo (Labjor) of Universidade de Campinas (Unicamp) is a reference in science communication and journalism in Brazil. Other than the specialization course in science journalism, it also has various products for science communication, like the electronic magazine…

  Scientific communication of the researches of Programa de Pós-graduação em Psicobiologia of Universidade Federal de São Paulo, BP.JC

• Abstract

  One of the approaches that has been used in the search for mechanisms involved in the deleterious effects of sleep deprivation (SD) on memory, evaluates changes in neurotransmitter systems, which may involve neuropeptides. The gastrin-releasing peptide (GRP) interferes in the modulation of memory. Low and moderate doses of the agonist (Bombesin peptide), or high doses of the antagonist (R…

  Evaluation of the involvement of gastrin-releasing peptide system on performance of sleep deprived rats in the multiple trial inhibitory avoidance task, BP.MS

• Abstract

  On the last years, the research integrating immunopathology and psychobiology has increasingly shown the importance of the interaction between these two systems. Many progresses have been made by studying the modulation of cognitive functions by cytokines, and nowadays the literature indicates that the pro-inflammatory cytokines, mainly IL-1², IL-6 and TNF-±, play an important role as mod…

  Memory evaluation of C3H/HeJ mice after IL-1beta treatment, BP.IC

(Only some records are available in English at this moment)