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Ministério da Saúde (Brasil). Fundação Oswaldo Cruz (Fiocruz). Plataforma de Pesquisa e Medicina Translacional (Institutional affiliation from the last research proposal) Birthplace: Brazil
João Santana da Silva in research grants and scholarships supported by FAPESP.
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
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Leishmaniasis is one of the most neglected infectious diseases worldwide. Its transmission occurs through the bite of infected sandflies. In this environment, the interaction between vector saliva, parasites and host cells occurs. Neutrophils are the first cells to migrate and their interaction with antigen-presenting cells is crucial in setting up the immune response. IL-17, the main cyt…
The purpose of the FACSymphony A5 SE Flow Cytometer is to analyze (phenotipar) distinct cellular populations of samples containing mixtures of cells, such as peripheral blood, lymphoid tissues, tumours, solid organs or other fabrics. (AU)
The purpose of the Cell Sorter Aria III CDU 5B/3R/6V is to analyze and separate distinct cell populations from samples containing mixtures of cells, such as peripheral blood, lymphoid tissues, tumors, solid organs, or other tissues. The equipment will be part of the equipment park of the Translational Medicine Research Platform - Fiocruz/Ribeirão Preto School of Medicine - USP, and will b…
(Only some records are available in English at this moment)
This is a project with two main objectives. The first is to set up a mycology laboratory to support and train students (graduate and post-docs), including giving discipline on the relationship between hosts and pathogenic fungi. As is known, the number of fungal infections has increased in recent decades, representing a critical threat to human health. These infections are observed both i…
Emerging and re-emerging diseases are a major public health problem. In the past years, the world has been threatened by several important emerging or re-emerging infectious diseases, such as Ebola, Avian Influenza A, Yellow Fever (YFV), Dengue (DENV), West Nile Fever (WNV) among others. In Brazil, the emerging infections caused by arboviruses such as DENV and YIF are historical and have …
In the last 15 years, my lab has dedicated to understand the mechanisms by which Plasmodium infection stimulate the innate immune responses and what is the outcome of these responses in host resistance to infection and pathogenesis of malaria. The current research program includes three projects around a main theme, which is "Immunological mechanisms of host resistance and disease in mala…
(Only some records are available in English at this moment)
Paracoccidioidomycosis (PCM) is a systemic fungal infection caused by a dimorphic fungus, the main species of which is Paracoccidioides brasiliensis. Furthermore, the fungus is endemic to the Americas. The regulatory immune response is important for a balanced physiological homeostasis in the case of a harmful pro-inflammatory response to the host. This regulatory response of the adaptive…
Leishmaniasis is a neglected disease of global relevance caused by protozoa of the genus Leishmania. The immune response to this infection is complex and involves the interaction of multiple cytokines and immune cells. Programmed death-1 (PD-1) is a co-inhibitory molecule expressed on T cells that regulates the immune response and plays a crucial role in maintaining immune tolerance and p…
This is a request for an IC scholarship for a previously selected candidate. The infectious disease model is using the human pathogenic fungus Paracoccidioides brasiliensis to evaluate viable fungi, isolate lung leukocytes and characterize them, prepare slides for histology and examine them, make fungal cultures and learn cytometry. With the development of this project, the student will h…
(Only some records are available in English at this moment)
This is a request for a CI scholarship for a candidate previously selected by the Brazilian Academy of Sciences. According to our understanding, this is a 50-day internship, to be completed here in our laboratory. The idea is that the student gets in touch with various techniques and that they can understand how they work until the end of the internship. Therefore, we developed an infecti…
The physiological balance provided by the regulation of the immune system is described as a critical point for the maintenance of homeostasis between specialized cells and cytokines. Thus, the function of inflammatory cytokines is well defined, among which the IL-12 family is known for its role in T helper lymphocytes. The IL-12 family consists of heterodimers that form five cytokines des…
(Only some records are available in English at this moment)
Malaria, caused by parasites from the genus Plasmodium, remains a major global health concern with millions of reported cases and deaths annually. The innate immune response involves PRRs that recognize malarial PAMPs and DAMPs, including those that promote the activation of cGAS-STING pathway. STING plays a pivotal role in immune responses against Plasmodium, inducing type I interferons …
Leishmaniasis is a disease transmitted by sand fly bites into host's skin, therefore the immune response against the parasite is initiated early in the skin, even in visceral cases. Murine models have shown that immune responses against Leishmania are very diverse, and may depend on the parasite species, strains and/or mice background. This is especially true for the roles played by infla…
The fungus Paracoccidioides brasiliensis is sensed by the Toll-like receptors 2, 4 (TLR2, 4) and dectin-1. The fungal recognition by dectin-1 is essential for NF-kB activation and induction of the expression of pro-IL-1B. The expression, maturation and secretion of IL-1B are processes tightly controlled. A major inflammatory pathway involved in the release of this cytokine is the activati…
(Only some records are available in English at this moment)
| 4 / 4 | Ongoing grants |
| 27 / 14 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 64 / 37 | Completed scholarships in Brazil |
| 8 / 8 | Completed scholarships abroad |
| 108 / 68 | All research grants and scholarships |
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