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Immunological mechanisms of resistance and disease in malaria

Abstract

In the last 15 years, my lab has dedicated to understand the mechanisms by which Plasmodium infection stimulate the innate immune responses and what is the outcome of these responses in host resistance to infection and pathogenesis of malaria. The current research program includes three projects around a main theme, which is "Immunological mechanisms of host resistance and disease in malaria". In the first project titled "Monocyte dendritic cells (MO-DCs) in malaria", we plan to evaluate the emergence of MO-DCs and the their pathogenic role in rodent malaria. In the second project titled "Killing of P. vivax infected reticulocytes by cytotoxic T cells" we provide evidences that P. vivax infected reticulocytes express HLA-I (MHC class I) and are killed by CD8+ T cells from malaria patients. We intent to evaluate the competence of reticulocytes to present endogenous antigens via HLA-I and the mechanism of intracellular parasite killing by CD8+ cytotoxic T cells. Finally, third project is titled "Immunology of asymptomatic malaria and the effects of immunity on Plasmodium transmission". In this project, we propose to identify innate immune biomarkers as well as B and T cell responses that are predictive of disease outcome and mosquito transmission. If successful, our studies will provide important information for monitoring silent infection in infective asymptomatic individuals and potentially new insights to further control malaria transmission in hypo-endemic areas. In summary, by using ex vivo, in vitro and in vivo experimental models, we intent to elaborate cell biology and immunological questions that will allow us to address the mechanisms of host resistance and pathogenesis of malaria. In the third project we intent to apply some of the hypothesis raised in the lab to define mechanisms that are potentially involved in modulating the systemic inflammation and preventing parasite elimination in asymptomatic malaria patients, and therefore, main impediment for eliminating parasite transmission in hypo-endemic areas of malaria. (AU)

Articles published in Pesquisa FAPESP Magazine about the research grant:
Standing alone 
Para caminar por sus propios medios 
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Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ALMEIDA, GREGORIO GUILHERME; CARVALHO COSTA, PEDRO AUGUSTO; ARAUJO, MAISA DA SILVA; GOMES, GABRIELA RIBEIRO; CARVALHO, ALEX FIORINI; FIGUEIREDO, MARIA MARTA; PEREIRA, DHELIO BATISTA; TADA, MAURO SHUGIRO; MEDEIROS, JANSEN FERNANDES; SOARES, IRENE DA SILVA; CARVALHO, LUZIA HELENA; KANO, FLORA SATIKO; DE CASTRO, MARCIA CALDAS; VINETZ, JOSEPH MICHAEL; GOLENBOCK, DOUGLAS TAYLOR; DO VALLE ANTONELLI, LIS RIBEIRO; GAZZINELLI, RICARDO TOSTES. Asymptomatic Plasmodium vivax malaria in the Brazilian Amazon: Submicroscopic parasitemic blood infects Nyssorhynchus darlingi. PLoS Neglected Tropical Diseases, v. 15, n. 10 OCT 2021. Web of Science Citations: 0.
DINIZ, SUELEN QUEIROZ; TEIXEIRA-CARVALHO, ANDREA; FIGUEIREDO, MARIA MARTA; CARVALHO COSTA, PEDRO AUGUSTO; ROCHA, BRUNO COELHO; MARTINS-FILHO, OLINDO ASSIS; GONCALVES, A. RICARDO; PEREIRA, DHELIO BATISTA; TADA, MAURO SHUGIRO; OLIVEIRA, FABIANO; GAZZINELLI, RICARDO TOSTES; DO VALLE ANTONELLI, LIS RIBEIRO. Plasmodium vivax Infection Alters Mitochondrial Metabolism in Human Monocytes. MBIO, v. 12, n. 4 JUL-AUG 2021. Web of Science Citations: 0.
JUNQUEIRA, CAROLINE; POLIDORO, RAFAEL B.; CASTRO, GUILHERME; ABSALON, SABRINA; LIANG, ZHITAO; SEN SANTARA, SUMIT; CRESPO, ANGELA; PEREIRA, DHELIO B.; GAZZINELLI, RICARDO T.; DVORIN, JEFFREY D.; LIEBERMAN, JUDY. gamma delta T cells suppress Plasmodium falciparum blood-stage infection by direct killing and phagocytosis. NATURE IMMUNOLOGY, v. 22, n. 3 JAN 2021. Web of Science Citations: 1.
PEREIRA, LARISSA M. N.; ASSIS, PATRICIA A.; DE ARAUJO, NATALIA M.; DURSO, DANIELLE F.; JUNQUEIRA, CAROLINE; ATAIDE, MARCO ANTONIO; PEREIRA, DHELIO B.; LIEN, EGIL; FITZGERALD, KATHERINE A.; ZAMBONI, DARIO S.; GOLENBOCK, DOUGLAS T.; GAZZINELLI, RICARDO T. Caspase-8 mediates inflammation and disease in rodent malaria. NATURE COMMUNICATIONS, v. 11, n. 1 SEP 14 2020. Web of Science Citations: 3.
PRIOR, KIMBERLEY F.; RIJO-FERREIRA, FILIPA; ASSIS, PATRICIA A.; HIRAKO, ISABELLA C.; WEAVER, DAVID R.; GAZZINELLI, RICARDO T.; REECE, SARAH E. Periodic Parasites and Daily Host Rhythms. CELL HOST & MICROBE, v. 27, n. 2, p. 176-187, FEB 12 2020. Web of Science Citations: 0.
ANTONELLI, LIS R.; JUNQUEIRA, CAROLINE; VINETZ, JOSEPH M.; GOLENBOCK, DOUGLAS T.; FERREIRA, MARCELO U.; GAZZINELLI, RICARDO T. The immunology of Plasmodium vivax malaria. IMMUNOLOGICAL REVIEWS, v. 293, n. 1, SI, p. 163-189, JAN 2020. Web of Science Citations: 0.
HIRAKO, ISABELLA C.; ASSIS, PATRICIA A.; GALVAO-FILHO, BRUNO; LUSTER, ANDREW D.; ANTONELLIL, LIS R. V.; GAZZINELLI, RICARDO T. Monocyte-derived dendritic cells in malaria. Current Opinion in Microbiology, v. 52, p. 139-150, DEC 2019. Web of Science Citations: 0.
JUNQUEIRA, CAROLINE; BARBOSA, CAMILA R. R.; COSTA, PEDRO A. C.; TEIXEIRA-CARVALHO, ANDREA; CASTRO, GUILHERME; SEN SANTARA, SUMIT; BARBOSA, RAFAEL P.; DOTIWALA, FAROKH; PEREIRA, DHELIO B.; ANTONELLI, LIS R.; LIEBERMAN, JUDY; GAZZINELLI, RICARDO T. Cytotoxic CD8(+) T cells recognize and kill Plasmodium vivax-infected reticulocytes. Nature Medicine, v. 24, n. 9, p. 1330+, SEP 2018. Web of Science Citations: 12.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.