| Grant number: | 13/00981-1 |
| Support type: | Scholarships in Brazil - Doctorate (Direct) |
| Effective date (Start): | August 01, 2013 |
| Effective date (End): | July 31, 2018 |
| Field of knowledge: | Biological Sciences - Parasitology - Protozoology of Parasites |
| Principal researcher: | Cláudio Romero Farias Marinho |
| Grantee: | Oscar Javier Murillo Gómez |
| Home Institution: | Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
| Associated research grant: | 09/53889-0 - Study of the immunopathological mechanisms involved in pregnancy-associated malaria, AP.JP |
Abstract Each year at least 50 million pregnant women are exposed to Plasmodium. Malaria during pregnancy (MiP, the English "Malaria in Pregnancy") is characterized by the sequestration of parasites in the placenta, and consequent maternal anemia, intrauterine growth retardation and decreased fetal viability. Frequently is observed a recrudescence of the infection during pregnancy, suggesting a complex pathogenic mechanism linked to an imbalance of the immune response. Despite the great advances made in the understanding of immunological aspects of the disease and its relation to pregnancy, the mechanisms involved in protection, especially those needed to maintain a balance between the beneficial and harmful immune response there still remain unclear. Recent evidence suggests the importance of dendritic cells (DCs) in regulating the immune response during infection of pregnant. This form, this project has the final objective the understanding the role of these cells in the resurgence of malaria in pregnancy. (AU) | |
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