Recrudescence of the malaria during pregnancy: effects and mechanisms

• Grant number: 18/20468-0
• Support Opportunities: Regular Research Grants
• Duration: March 01, 2019 - February 28, 2021
• Field of knowledge: Biological Sciences - Parasitology - Protozoology of Parasites
• Principal Investigator: Cláudio Romero Farias Marinho
• Grantee: Cláudio Romero Farias Marinho
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Lígia Antunes Gonçalves ; Sabrina Epiphanio

Abstract

It is estimated that approximately 125 million women in endemic Plasmodium countries get pregnant every year and, therefore, face an increased risk of acquiring malaria followed by its complications. Frequently is observed a recrudescence of the infection during pregnancy, suggesting a complex pathogenic mechanism linked to an imbalance of the immune response responsible for infection control. Despite the great advances made in the understanding of immunological aspects of the disease and its relation to pregnancy, the mechanisms involved in protection, especially those needed to maintain a balance between the beneficial and harmful immune response there still remain unclear. Recent evidence suggests the importance of dendritic cells in regulating the immune response during infection of pregnant women. Then, this project has the final objective of understanding the role of these cells in the resurgence of malaria in pregnancy. (AU)

Scientific publications

(15)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BARATEIRO, ANDRE; PEREIRA, MARCELO L. M.; EPIPHANIO, SABRINA; MARINHO, CLAUDIO R. F.. Contribution of Murine Models to the Study of Malaria During Pregnancy. FRONTIERS IN MICROBIOLOGY, v. 10, JUN 19 2019. (12/10081-5, 17/05782-8, 17/03939-7, 18/20468-0)

LAZARI, LUCAS CARDOSO; GHILARDI, FABIO DE ROSE; ROSA-FERNANDES, LIVIA; ASSIS, DIEGO M.; NICOLAU, JOSE CARLOS; SANTIAGO, VERONICA FEIJOLI; DALCOQUIO, TALIA FALCAO; ANGELI, CLAUDIA B.; BERTOLIN, ADRIADNE JUSTI; MARINHO, CLAUDIO R. F.; et al. Prognostic accuracy of MALDI-TOF mass spectrometric analysis of plasma in COVID-19. LIFE SCIENCE ALLIANCE, v. 4, n. 8, AUG 2021. (20/04705-2, 18/15549-1, 17/03966-4, 15/26722-8, 18/20468-0, 20/04923-0, 18/18257-1)

DOBRESCU, IRINA; DE CAMARGO, TARSILA MENDES; GIMENEZ, ALBA MARINA; MURILLO, OSCAR; AMORIM, KELLY NAZARE DA SILVA; MARINHO, CLAUDIO ROMERO FARIAS; SOARES, IRENE SILVA; BOSCARDIN, SILVIA BEATRIZ; BARGIERI, DANIEL YOUSSEF. Protective Immunity in Mice Immunized With P. vivax MSP1(19)-Based Formulations and Challenged With P. berghei Expressing PvMSP1(19). FRONTIERS IN IMMUNOLOGY, v. 11, FEB 19 2020. (13/13119-6, 14/50631-0, 12/13032-5, 14/23083-1, 18/17364-9, 18/20468-0)

REIS, ARAMYS S.; BARBOZA, RENATO; MURILLO, OSCAR; BARATEIRO, ANDRE; PEIXOTO, ERIKA P. M.; LIMA, FLAVIA A.; GOMES, VINICIUS M.; DOMBROWSKI, JAMILLE G.; LEAL, VINICIUS N. C.; ARAUJO, FRANCIELE; et al. Inflammasome activation and IL-1 signaling during placental malaria induce poor pregnancy outcomes. SCIENCE ADVANCES, v. 6, n. 10, MAR 2020. (14/09964-5, 15/23395-6, 14/20451-0, 17/03939-7, 11/19048-8, 17/05782-8, 13/16417-8, 16/07030-0, 12/16525-2, 12/04755-3, 15/50650-7, 18/20468-0, 13/00981-1, 11/17880-8, 15/06106-0)

BENAVENTE, ERNEST DIEZ; MANKO, EMILIA; PHELAN, JODY; CAMPOS, MONICA; NOLDER, DEBBIE; FERNANDEZ, DIANA; VELEZ-TOBON, GABRIEL; TOBON CASTANO, ALBERTO; DOMBROWSKI, JAMILLE G.; MARINHO, CLAUDIO R. F.; et al. Distinctive genetic structure and selection patterns in Plasmodium vivax from South Asia and East Africa. NATURE COMMUNICATIONS, v. 12, n. 1, MAY 26 2021. (19/12068-5, 18/20468-0)

DOMBROWSKI, JAMILLE GREGORIO; BARATEIRO, ANDRE; MACHADO PEIXOTO, ERIKA PAULA; CLAUDIO DA SILVA BARROS, ANDRE BOLER; DE SOUZA, RODRIGO MEDEIROS; CLARK, TAANE GREGORY; CAMPINO, SUSANA; WRENGER, CARSTEN; WUNDERLICH, GERHARD; PALMISANO, GIUSEPPE; et al. Adverse pregnancy outcomes are associated with Plasmodium vivax malaria in a prospective cohort of women from the Brazilian Amazon. PLoS Neglected Tropical Diseases, v. 15, n. 4, APR 2021. (17/03966-4, 17/03939-7, 18/18257-1, 19/12068-5, 15/26722-8, 17/24267-7, 20/06747-4, 18/20468-0, 20/04923-0, 18/15549-1, 17/05782-8)

KASSA, MESERET W.; HASANG, WINA; BARATEIRO, ANDRE; DAMELANG, TIMON; BREWSTER, JESSICA; DOMBROWSKI, JAMILLE G. G.; LONGLEY, RHEA J. J.; CHUNG, AMY W.; WUNDERLICH, GERHARD; MUELLER, IVO; et al. Acquisition of antibodies to Plasmodium falciparum and Plasmodium vivax antigens in pregnant women living in a low malaria transmission area of Brazil. Malaria Journal, v. 21, n. 1, p. 14-pg., 2022-12-01. (19/12068-5, 18/20468-0, 17/50181-2, 17/03939-7)

MACEDO-DA-SILVA, JANAINA; SANTIAGO, VERONICA F.; ROSA-FERNANDES, LIVIA; MARINHO, CLAUDIO R. F.; PALMISANO, GIUSEPPE. Protein glycosylation in extracellular vesicles: Structural characterization and biological functions. Molecular Immunology, v. 135, p. 226-246, JUL 2021. (18/15549-1, 18/20468-0, 18/18257-1, 20/04923-0)

DOMBROWSKI, JAMILLE GREGORIO; DE SOUZA, RODRIGO MEDEIROS; LIMA, FLAVIA AFONSO; BANDEIRA, CARLA LETICIA; MURILLO, OSCAR; COSTA, DOUGLAS DE SOUSA; MACHADO PEIXOTO, ERIKA PAULA; CUNHA, MARIELTON DOS PASSOS; DE ANDRADE ZANOTTO, PAOLO MARINHO; BEVILACQUA, ESTELA; et al. Association of Malaria Infection During Pregnancy With Head Circumference of Newborns in the Brazilian Amazon. JAMA NETWORK OPEN, v. 2, n. 5, MAY 2019. (14/17766-9, 18/20468-0, 12/04755-3, 13/21728-2, 14/20451-0, 14/09964-5, 15/06106-0, 13/00981-1, 16/08204-2, 13/16417-8, 09/53889-0)

SANTOS PEREIRA, DOMINGOS MAGNO; CARVALHO JUNIOR, ALEXSANDER RODRIGUES; DA COSTA BRITO LACERDA, ELIZA MARIA; NASCIMENTO DA SILVA, LUIS CLAUDIO; FARIAS MARINHO, CLAUDIO ROMERO; ANDRE, EUNICE; FERNANDES, ELIZABETH SOARES. Oxidative and nitrosative stresses in cerebral malaria: can we target them to avoid a bad prognosis?. Journal of Antimicrobial Chemotherapy, v. 75, n. 6, p. 1363-1373, JUN 2020. (18/20468-0)

LIMA, FLAVIA AFONSO; BARATEIRO, ANDRE; DOMBROWSKI, JAMILLE GREGORIO; DE SOUZA, RODRIGO MEDEIROS; COSTA, DOUGLAS DE SOUSA; MURILLO, OSCAR; EPIPHANIO, SABRINA; GONCALVES, LIGIA ANTUNES; FARIAS MARINHO, CLAUDIO ROMERO. Plasmodium falciparum infection dysregulates placental autophagy. PLoS One, v. 14, n. 12, DEC 5 2019. (17/03939-7, 17/05782-8, 13/16417-8, 12/04755-3, 16/07030-0, 15/06106-0, 13/00981-1, 18/20468-0)

GOMES, LAURA CORDEIRO; SANSON, MARINA CORDEIRO GOMES; BRAININ, PHILIP; DE MELO, MARIA DA CONCEICAO VIEIRA; DE SOUZA, RODRIGO MEDEIROS; MAZARO, JANAINA; LIMA, KARINE OLIVEIRA; RESENDE, JUNIA SILVA; VIEIRA, ISABELLE VICTORIA MARTINS; MESQUITA, EDINILSON DA SILVA; et al. Levels of hepatitis B antibody titers are affected by age and doses gap time in children from a high endemic area of the western Amazon. PLoS One, v. 16, n. 7, 2021. (18/20468-0, 18/18257-1, 18/15549-1, 15/26722-8, 14/06863-3)

MACEDO-DA-SILVA, JANAINA; MARINHO, CLAUDIO ROMERO FARIAS; PALMISANO, GIUSEPPE; ROSA-FERNANDES, LIVIA. Lights and Shadows of TORCH Infection Proteomics. GENES, v. 11, n. 8, p. 31-pg., 2020-08-01. (14/06863-3, 18/20468-0, 18/18257-1, 18/15549-1)

LAZARI, LUCAS C.; ZERBINATI, RODRIGO M.; ROSA-FERNANDES, LIVIA; SANTIAGO, VERONICA FEIJOLI; ROSA, KLAISE F.; ANGELI, CLAUDIA B.; SCHWAB, GABRIELA; PALMIERI, MICHELLE; SARMENTO, DMITY J. S.; MARINHO, CLAUDIO R. F.; et al. ALDI-TOF mass spectrometry of saliva samples as a prognostic tool for COVID-1. OURNAL OF ORAL MICROBIOLOG, v. 14, n. 1, DEC 31 2022. (18/15549-1, 20/06409-1, 20/04923-0, 18/18257-1, 15/26722-8, 17/03966-4, 21/07490-0, 18/20468-0)

SANTIAGO, VERONICA FEIJOLI; DOMBROWSKI, JAMILLE GREGORIO; KAWAHARA, REBECA; ROSA-FERNANDES, LIVIA; MULE, SIMON NGAO; MURILLO, OSCAR; SANTANA, THAIS VIGGIANI; PACCINI COUTINHO, JOAO VICTOR; MACEDO-DA-SILVA, JANAINA; LAZARI, LUCAS CARDOSO; et al. Complement System Activation Is a Plasma Biomarker Signature during Malaria in Pregnancy. GENES, v. 14, n. 8, p. 20-pg., 2023-08-01. (21/14751-4, 18/15549-1, 20/06747-4, 20/04923-0, 17/04032-5, 21/00140-3, 19/12068-5, 18/20468-0)