Graduated in Pharmaceutical Biochemistry from the Ribeirão Preto School of Pharmaceutical Sciences (FCFRP-USP).Earned a Masters in Basic and Applied Immunology and a PhD from the Department of Medical Clinic at the Ribeirão Preto School of Medicine (FMRP-USP). Completed postdoctoral research at the Department of Medical Clinic, FMRP-USP. Currently, she is a Scientific and Technological Researcher at the Blood Center of Ribeirão Preto. She is the Supervisor of the Molecular Biology Branch at the Blood Center of Ribeirão Preto and the Technical Manager of the Advanced Molecular Biology Laboratory. She has extensive experience in Virology, Immunology, Genetics, and Molecular Biology, with a focus on infectious diseases impacting cell therapy and the molecular characterization of emerging viral infections. Her research includes basic studies on the biology of stem cells and the cellular components of the hematopoietic niche in sickle cell disease. She also has expertise in quality control for molecular tests and in the development of molecular platforms for diagnostic purposes. She serves as Principal Investigator at the Center for Viral Surveillance and Serological Evaluation (CeViVas/FAPESP). She is an active member of several international organizations, including the Transfusion Transmitted Infectious Diseases Working Party of the International Society of Blood Transfusion (ISBT), the Advisory Board of the European Global Health Research Institutes Network (EGHRIN), and the Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular (ABHH) and International Society of Blood Transfusion (ISBT). She is also a member of the Executive Secretariat Animal/Human Sector of the National Technical Biosafety Commission (CTNBio), linked to the Ministry of Science, Technology, and Innovations. (Source: Lattes Curriculum)
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Sickle Cell Anemia (SCA) is a complex hematological disorder encompassing dysregulated hematopoiesis and chronic inflammation within the bone marrow. This interdisciplinary project investigates the molecular intricacies of bone marrow aspirates from three distinct subject groups: healthy donors (control group), chronically transfused SCA patients, and hydroxyurea-treated SCA patients (stu…
The bone marrow microenvironment and its cellular and molecular complexity in sickle cell anemia (SCA) are still poorly understood. SCA is a genetic disease characterized by the synthesis of an altered hemoglobin, HbS. Under hypoxia, HbS polymerizes and results in hemolysis and episodes of vaso-occlusion, leading to important clinical complications, with evident inflammation. The conseque…
Vaccination is the touchstone of public health policies. The history of vaccination shows that vaccines have been empirically developed; therefore, many studies are still needed for the continuous development of this biological product. The effectiveness of vaccines is evaluated through the reduction of the infection or illness among vaccinated individuals, and it is influenced by many fa…
With the rapid dissemination of Zika virus (ZIKV) in the Tropical world and its entry in Brazil, a rapid strategy with interaction of different scientific areas is necessary in order to understand better the infection pathogenesis. A significant number of studies performed in Brazil are destined towards understanding ZIKV biology; nevertheless, specific efforts are necessary for the devel…
The transmission of infectious diseases by the transfusion of contaminated blood components has constantly decreased due to great advancements in molecular methods for diagnostic investigation. The Nucleic Acid Technologies (NAT) for the hepatitis C virus (HCV) and for the human immunodeficiency virus (HIV) has been recommended by the Brazilian law since 2002 (Ordinance n° 262/2002 of Min…
Sickle Cell Anemia (SCA) is a complex hematological disorder encompassing dysregulated hematopoiesis andchronic inflammation within the bone marrow. This interdisciplinary project investigates the molecular intricaciesof bone marrow aspirates from three distinct subject groups: healthy donors (control group), chronicallytransfused SCA patients, and hydroxyurea-treated SCA patients (study …
Dengue is an arboviral fever caused by four distinct Dengue virus (DENV) serotypes, transmitted by the bite of Aedes mosquitoes. About 390 million infections occur annually in tropical and subtropical countries. Brazil has the highest number of DENV infections among Latin American countries. The northwest of the State of São Paulo is considered an endemic area for the infection. In this r…
Sickle cell anemia (SCA) is a disease in which a point mutation in the beta-globin chain (HbB) gene, type A - T, leads to the synthesis of "S" globins and formation of hemoglobins (HbS) that polymerize within the red blood cells, changing their biconcave structure making them sickle. These cells present greater dehydration and endothelial adhesion, in addition to a high degree of hemolysi…
The hematopoietic niche is a highly dynamic, orchestrated and heterogeneous microenvironment for the cell types that make up. This microenvironment acts on the regulation of the hematopoietic system, which is the controller of the production of all the blood cells of the organism in homeostasis or stress. Among the cell types that make up the niche, there are Multipotent Mesenchymal Strom…
Red blood cell alloimmunization in sickle cell disease (SCD) affects more than 30% of individuals in transfusion therapy. It is the main complication related to blood transfusion in SCD and may be related to the antigenic disparity between donors and patients or with a deficiency in the control of the cellular immune response. The prophylaxis adopted to prevent alloimmunization is to supp…
(Only some records are available in English at this moment)
Dengue fever is caused by four distinct serotypes of the dengue virus (DENV), which are transmitted by Aedes mosquitoes. Approximately 390 million infections occur annually in tropical and subtropical countries. This infection is endemic in the northwest region of the State of São Paulo, with co-circulation of DENV1 and DENV2 serotypes. Around 25% of DENV infections progress to clinical m…
Human T cell lymphotropic virus type 1 (HTLV-1) was the first human retrovirus to be discovered. Approximately, 10 - 20 million people are infected with HTLV-1 worldwide, and in Brazil, there are about 2.5 million HTLV-1-carriers. The main HTLV-1-associated diseases are the HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and the adult T cell leukemia/lymphoma (ATL). Cu…
| 3 / 3 | Ongoing grants |
| 2 / 2 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 13 / 8 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 22 / 17 | All research grants and scholarships |
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CV Lattes
ORCID