CV Lattes
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Universidade de São Paulo (USP). Faculdade de Odontologia de Bauru (FOB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Dentistry from the Bauru School of Dentistry (FOB), USP (1992), Master in Dentistry, area of #8203;#8203;Periodontics, FOB-USP (1995) and Ph.D. in Functional and Molecular Biology from UNICAMP (1999) and Specialist in Orofacial Harmonization (2021). She was (2011-2014) Member of the Awards Review Committee of the International Association for Dental Research (IADR) and Member of the Board of the European Organization for Research in Caries (ORCA). She was Chair of the IADR Cariology group (2019-2020) and coordinator of the Health Area II (Dentistry) at FAPESP (2018-2022. He was Head of the Department of Biological Sciences (2006-2010) and President of the Research Committee (2014-2018) at FOB-USP. She was Associate Editor of the Journal of Applied Oral Sciences and the International Journal of Dentistry. She is currently Full Professor at the Department of Biological Sciences and Dean of FOB-USP, 1A researcher at CNPq and Editor of the Monographs in Oral Science series (Karger). She has expertise in Dentistry, with emphasis on Cariology, Oral Biochemistry and Orofacial Harmonization, acting on the following topics: fluorides, dental fluorosis, dental caries, dental erosion, bacterial biofilm, acquired film, toxicology, proteomics and autologous platelets aggregates. Member of the Brazilian Academy of Dentistry (chair 69) since 2021. Received more than 70 awards, highlighting the Basil Bibby Young Investigator Award in Cariology (IADR, 2008) and the IADR Distinguished Scientist Award H. Trendley Dean Memorial Award (2014). She has published 5 books and more than 500 articles in journals with a selective editorial policy. She presents h factor = 46, with 9,268 citations (Web of Science) and h=73 with 20,546 citations at Google Scholar. She is among the most influent researchers of the world (Position 31.316/223.153; ranking de Stanford, Ioannidis, John P.A. (2024), August 2024 data-update for "Updated science-wide author databases of standardized citation indicators", Elsevier Data Repository, V7, doi: 10.17632/btchxktzyw.7) and of University of São Paulo (position 11/249). According to the same ranking, in Dentistry, she ranks 2nd among 94 Brazilian researchers and 1st among researchers from the State of São Paulo. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| Por una blanca sonrisa |
| White smile |
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Molecular studies (genomics, proteomics) have been increasingly integrated into traditional taxonomic methods to provide more robust data, aiding in the processes of species delimitation, characterization, and identification. Moreover, when combined with other tools, such as oxidative biochemical responses, these methods can serve as biomarkers of environmental damage caused by toxicants …
Obesity, Gestational Diabetes Mellitus (GDM) and pregnancy hormones may have synergistic effects on periodontal tissues. Although there are epidemiological findings that associate these outcomes, this association is uncertain and may be misinterpreted due to a variety of confounding factors. Furthermore, the pathophysiological mechanisms related to the association between obesity or GDM w…
The portions of the technical reserve for institutional infrastructure costs for research, provided by FAPESP for the fiscal year 2024 (base year 2023), amounting to R$ 127,325.43, and the balance for the fiscal year 2023 (base year 2022), amounting to R$ 64,453.29, will be allocated to the installation of four new energy generators purchased with the 2023 institutional technical reserve,…
(Only some records are available in English at this moment)
Despite being easily preventable, carie is the most prevalent chronic disease worldwide. In the thematic project associated with this proposal (FAPESP 2019/26070-1), we proposed a completely new concept for the prevention of dental caries, through engineering of acquired enamel pellicle (AEP). Modification of the protein profile of this integument, by incorporating acid-fast proteins, suc…
Dentistry and speech therapy clinics, as well as research laboratories, have several high-cost equipment, many of which are available on the multi-user platform, used in the development of clinical research activities and in the laboratory environment of this university. With several cases of power supply interruptions, these equipment are vulnerable and susceptible to electrical damage. …
Resveratrol is a polyphenol naturally produced by 72 different species of plants, with emphasis on grapes, vegetables, peanuts, soybeans and pomegranates. It has been widely studied for its different beneficial health effects, since it has antioxidant, anti-inflammatory, immunomodulatory and neuroprotective properties, which means that its consumption is associated with a reduction in cho…
(Only some records are available in English at this moment)
Molecular studies have been increasingly incorporated into traditional taxonomy methods with the aim of providing more robust data, aiding in the process of species delimitation, characterization, and identification. In addition, when combined with other tools such as oxidative biochemical responses, they can serve as biomarkers of environmental damage caused by toxicants such as mercury.…
Fluoride (F) is widely used in public health due to its benefits in preventing dental caries but also presents toxicity when consumed in excess, causing metabolic and cellular alterations as well as fluorosis. Recent studies have highlighted sex-related differences in responses to fluoride, linked to metabolic factors. A relevant aspect of this research is the relationship between fluorid…
The presence of the acquired enamel pellicle (AEP) plays a crucial role in protecting against erosive tooth wear (ETW). With advances in omics techniques, acid-resistant proteins have been identified in the AEP, encouraging the development of "acquired pellicle engineering" strategies. These strategies aim to enrich the AEP with proteins that have a high affinity for hydroxyapatite, remai…
(Only some records are available in English at this moment)
The project aims to investigate the effects of CaneCPI-5, with or without fluoride, on the prevention of enamel demineralization and on the remineralization of artificial enamel lesions in situ. Initially, bovine enamel samples (4 mm x 4 mm, n=240) will be polished and subjected to initial surface microhardness analysis (5 Knoop indentations, 25 g, 10s). Half of the samples will remain so…
The presence of acquired enamel pellicle (AEP) is one of the protective factors against erosive tooth wear (ETW) and dental caries. With the advancement of omics techniques, acid-resistant proteins have been identified in the AEP, which has stimulated "acquired pellicle engineering" procedures, focused on enriching this integument with proteins with high capacity to bind to hydroxyapatite…
The incorporation of proteins (eg CaneCPI-5) into the acquired pellicle (AP) has favored its ability to protect against erosion. In this context, a new cysteine protease inhibitor protein (cystatin) derived from Maqui Berry (MaquiCPI-3) deserves to be studied, due to some characteristics similar to CaneCPI-5 and its high yield when heterologously expressed in bacteria. Initial in vitro re…
(Only some records are available in English at this moment)
Gestational Diabetes Mellitus (GDM) and periodontitis are prevalent conditions during pregnancy and are independently associated with systemic inflammation and adverse maternal-fetal outcomes. Hormonal, immunological, and metabolic alterations during gestation may influence periodontal health, while periodontitis itself may contribute to glycemic dysregulation through chronic low-grade in…
The study focuses on modifying the acquired pellicle (AP), a crucial factor in protecting against dental caries, erosive tooth wear, and biofilm modification. Advances in "omic" techniques have revealed acid-resistant proteins in AP, driving the "acquired pellicle engineering procedures". Thus, enrich this layer with proteins highly binding to hydroxyapatite, potentially influencing biofi…
Fluoride (F) is an important agent for dental caries control, being applied preventively in artificially fluoridated public water supplies. Animal studies from our group have shown that low doses of fluoride in drinking water, similar to those found in public water supplies, increase insulin sensitivity and reduce blood glucose levels in diabetic rodents. Recently, we observed that NOD mi…
Acquired enamel pellicle (AEP) engineering, by immobilizing molecules with high binding capacity to hydroxyapatite and resistance to removal by acids, is a new strategy for controlling erosive tooth wear (ETW). Our group has been employing a statherin-derived peptide (StN15pSpS) in strategies of this type. Polyphenols, such as epigallocatechin-3-gallate (EGCG), are readily adsorbed to AEP…
The formation of a white spot lesion (WSL) around orthodontic accessories is considered a reversible iatrogenesis, with a high frequency of occurrence. The presence of different bacteria and their degrees of pathogenicity in dysbiotic biofilm related to dental caries is recent. In addition, no studies relate the action of a high fluoride concentration on the cariogenic biofilm in vivo. Id…
Resveratrol is a polyphenol naturally produced by different plant species, which has been widely studied for its different beneficial health effects, since it has antioxidant, anti-inflammatory, immunomodulatory and neuroprotective properties. Its consumption is associated with a reduction in cholesterol levels, obesity, cardiovascular risk and prevention of diabetes, in addition to havin…
(Only some records are available in English at this moment)
| 8 / 8 | Ongoing grants |
| 45 / 32 | Completed research grants |
| 18 / 18 | Ongoing scholarships in Brazil |
| 139 / 105 | Completed scholarships in Brazil |
| 3 / 3 | Ongoing scholarships abroad |
| 18 / 18 | Completed scholarships abroad |
| 231 / 184 | All research grants and scholarships |
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