CV Lattes
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Secretaria da Saúde (São Paulo - Estado). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Ciências Biológicas from Universidade de São Paulo (1999) and doctorate at Immunology from Universidade de São Paulo (2004). Has experience in Immunology, focusing on Immunology, acting on the following subjects: hiv, células dendríticas, ascaris suum, vacina terapêutica and monoclonal antibodies. (Source: Lattes Curriculum)
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Dendritic cells (DCs) based immunotherapy constitutes a potential tool to induce protective immunity and can act as an adjuvant treatment to antiretroviral therapy in the context of HIV infection. DCs interact with TCD4+ and TCD8+ lymphocytes, presenting antigens and initiating specific immune responses. In turn, the immune microenvironment is also composed of cellular subpopulations asso…
Immunotherapy based on monocyte derived dendritic cells constitutes a promising strategy for the treatment of individuals infected with HIV. Protocols for obtaining conventional DCs use mediators of cell differentiation like IL4 and GMCSF that differentiate monocytes to immature DCs with myeloid cell characteristics. The stimulation with pro-inflammatory cytokines (TNF-alpha, IL-1beta and…
Immunotherapy based on monocyte-derived dendritic cells (MoDCs) is a promising strategy for the treatment of HIV-infected individuals. Due to its remarkable plasticity, heterogeneous populations of MoDCs can be obtained in vitro, depending on the culture conditions. Consequently, these cells could be differently able to secrete cytokines and to express molecules that participate in the pr…
It has been demonstrated that the progression of melanoma is closely related to an inflammatory microenvironment. In this sense, IL-1ß is an important pro-inflammatory mediator capable of coordinating the expression of other cytokines and chemokines, and mediate the recruitment of cells to the site of injury. In turn, the maturation of IL-1ß as well as its secretion is controlled by a cyt…
(Only some records are available in English at this moment)
Cellular immunotherapy is a promising method with increasing application in Brazil and around the world. Dendritic cell-based immunotherapy depends on obtaining precursor cells, usually monocytes present in peripheral blood, which are differentiated in vitro into moDCs. Precursor cells are obtained through leukapheresis, collecting mononuclear cells, among which monocytes, precursors of m…
Immunotherapy based on monocyte derived dendritic cells (MoDCs) constitute a promises strategy for treatment of HIV infected patients. Protocols for obtention of mature MoDCs, properly capable to present antigen for specific T lymphocytes in general use IL-4 and GM-CSF cytokines as mediators of cell differentation, that originate DC's immature with myeloid characteristics. Stimulus with p…
It has been demonstrated that the progression of melanoma is closely related to an inflammatory microenvironment. In this sense, IL-1ß is an important pro-inflammatory mediator capable of coordinating the expression of other cytokines and chemokines, and mediate the recruitment of cells to the site of injury. In turn, the maturation of IL-1ß as well as its secretion is controlled by a cyt…
Immunotherapy based on monocyte-derived dendritic cells (MoDCs) is a promising strategy for the treatment of HIV-infected individuals. Due to its remarkable plasticity, heterogeneous populations of MoDCs can be obtained in vitro, depending on the culture conditions. Consequently, these cells could be differently able to secrete cytokines and to express molecules that participate in the pr…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing grants |
| 5 / 4 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 9 / 4 | Completed scholarships in Brazil |
| 16 / 10 | All research grants and scholarships |
| Associated processes | |