CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia (IB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduate at Ciências Biológicas from Universidade Estadual de Campinas (1987), master's at General Biology from Universidade Estadual de Campinas (1989) and ph.d. at Biochemistry from Universidade Estadual de Campinas (1993). Has experience in General Biology, acting on the following subjects: próstata, castração, desenvolvimento, prostate and tendões. (Source: Lattes Curriculum)
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WFDC1 is a highly conserved ancient gene encoding a small, secreted protein present in the extracellular matrix with critical roles in angiogenesis, cancer, immune response, and tissue repair. WFDC1 upregulation has been associated with changes in endothelial biomarkers, cardiac hypertrophy and cardiac failure. However, its specific role during normal cardiovascular development, adult hom…
The prostate is susceptible to different diseases including the prostatitis, benign prostate hyperplasia and prostate cancer. Prostate cancer will affect 12.5% of men in all ages and 50% of men at the age 85. Benign prostate hyperplasia will affect a larger number of younger men. Our interest is to study prostate physiology at the cell and molecular biology levels, to better understand th…
It is the acquisition of super-resolution microscope aproved in the INCT-INFABIC, inherently multi-user in character. (AU)
(Only some records are available in English at this moment)
(Only some records are available in English at this moment)
The origin of myofibroblasts and telocytes in the prostate is still unclear. It also unknown whether a single mesenchymal progenitor cell capable of giving rise to fibroblasts, smooth muscle cells, myofibroblasts and telocytes exist. In addition, little is known about the interrelationships among these cell types of the prostate stroma. Telocytes are CD34-positive interstitial cells, whic…
Human alpha (HBA) and beta-globin (HBB) genes are located in clusters in chromosomes 16 and 11, respectively, and are highly expressed in cells from the erythroid lineage. Recent work in our laboratory has identified globin expression in the rodent ventral prostate (mice and rats): newborns, castrated adults and mice fed with normolipidic lard-based diets. The latter presented variable bu…
The use of surgical or chemical castration in the treatment of advanced prostate cancer is based on the depletion of the androgenic stimulus to keep the proliferative state of epithelial cells. Employing surgical castration and DNA microarrays, we found increased expression of the Abcc3 transporter/pump and determined that its ABCC3 product is located in the baso-lateral portion of the ep…
(Only some records are available in English at this moment)
The exchange of extracellular vesicles has emerged as one of the main means for intercellular communication, these structures can carry a large set of information as they may contain, in addition to structural proteins and growth and differentiation factors, several types of RNAs, in particular, miRNA and mRNA, which indicates the potential of extracellular vesicles to directly modulate g…
Prostate morphogenesis, as in other branched organs, such as kidney, salivary gland and lung, depends on well regulated epithelial-stromal interactions. The two compartments exchange molecular clues either by ECM remodeling, cell contact or soluble signaling molecules. Some of these molecules, such as growth factors, bind to heparan sulfate proteoglycans (HSPGs), which dictate the dynamic…
Advanced stages of prostate cancer (PCa) involves growth in androgen-depleted environment, and the mechanisms underlying progression to androgen-independent prostate cancer following androgen deprivation or blockade therapies has attracted much attention. DNA microarray analysis conducted to determine comprehensive profiling of gene expression and extensive bioinformatics unveiled that My…
| 5 / 4 | Ongoing research grants |
| 43 / 19 | Completed research grants |
| 37 / 18 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 3 / 2 | Completed scholarships abroad |
| 89 / 44 | All research grants and scholarships |
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