CV Lattes
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ORCID
Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia (IB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Ciências Biológicas from Universidade Estadual de Campinas (1987), master's at General Biology from Universidade Estadual de Campinas (1989) and ph.d. at Biochemistry from Universidade Estadual de Campinas (1993). Has experience in General Biology, acting on the following subjects: prostate, castration, development and extracellular matrix. (Source: Lattes Curriculum)
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This is a proposition for the expenses related to the RTI for the year 2024. The proposition includes the acquisition of multiuser equipments and those needed for the climatization of laboratory spaces. The application also inclused an upgrade of the data processing/deposition system. (AU)
This is the proposal for the acquisition of a light sheet microscope (AU)
The prostate is susceptible to different diseases including the prostatitis, benign prostate hyperplasia and prostate cancer. Prostate cancer will affect 12.5% of men in all ages and 50% of men at the age 85. Benign prostate hyperplasia will affect a larger number of younger men. Our interest is to study prostate physiology at the cell and molecular biology levels, to better understand th…
The present application aims at upgrading the infrastructure of the Institute of Biology / Unicamp. In this way, the upgrade of the Institute network hardware, animal facilities improvements, electric instalation renewal and climatization of multiuser laboratories. (AU)
The present application aims at upgrading the infrastructure of the Institute of Biology / Unicamp. In this way, the upgrade of the Institute network hardware, animal facilities improvements, electric instalation renewal and climatization of multiuser laboratories. (AU)
WFDC1 is a highly conserved ancient gene encoding a small, secreted protein present in the extracellular matrix with critical roles in angiogenesis, cancer, immune response, and tissue repair. WFDC1 upregulation has been associated with changes in endothelial biomarkers, cardiac hypertrophy and cardiac failure. However, its specific role during normal cardiovascular development, adult hom…
(Only some records are available in English at this moment)
Zebrafish are an excellent model for studying diseases of genetic origin because they share high genetic and molecular similarities with humans. In particular, transgenesis and the study of processes involving hematopoietic cells have been widely studied using this fish as a model. Macrophages are cells that can have embryonic and hematopoietic origins and their development is quite conse…
Prostate devolpment is a complex phenomenon incuding prostate induction from the urogenital sinus, the growth of the prostate buds, the ductal canalization and branching. Along with these processes, there is an increasing complexity of the cell types found in both the epithelial layer and in the stroma of the organ. In this work we will employ the powerful technique scRNAseq to characteri…
The tendon is one of the most structurally complex tissues and when affected by diseases or injuries, it is difficult to regenerate and replace. In order to overcome these needs, tissue engineering has some resources that have been studied over the years, such as 3D bioprinting, electrospinning and microfluidics. 3D bioprinting is one of the technologies on the rise at the moment, it has …
The origin of myofibroblasts and telocytes in the prostate is still unclear. It also unknown whether a single mesenchymal progenitor cell capable of giving rise to fibroblasts, smooth muscle cells, myofibroblasts and telocytes exist. In addition, little is known about the interrelationships among these cell types of the prostate stroma. Telocytes are CD34-positive interstitial cells, whic…
Human alpha (HBA) and beta-globin (HBB) genes are located in clusters in chromosomes 16 and 11, respectively, and are highly expressed in cells from the erythroid lineage. Recent work in our laboratory has identified globin expression in the rodent ventral prostate (mice and rats): newborns, castrated adults and mice fed with normolipidic lard-based diets. The latter presented variable bu…
(Only some records are available in English at this moment)
The exchange of extracellular vesicles has emerged as one of the main means for intercellular communication, these structures can carry a large set of information as they may contain, in addition to structural proteins and growth and differentiation factors, several types of RNAs, in particular, miRNA and mRNA, which indicates the potential of extracellular vesicles to directly modulate g…
Prostate morphogenesis, as in other branched organs, such as kidney, salivary gland and lung, depends on well regulated epithelial-stromal interactions. The two compartments exchange molecular clues either by ECM remodeling, cell contact or soluble signaling molecules. Some of these molecules, such as growth factors, bind to heparan sulfate proteoglycans (HSPGs), which dictate the dynamic…
Advanced stages of prostate cancer (PCa) involves growth in androgen-depleted environment, and the mechanisms underlying progression to androgen-independent prostate cancer following androgen deprivation or blockade therapies has attracted much attention. DNA microarray analysis conducted to determine comprehensive profiling of gene expression and extensive bioinformatics unveiled that My…
| 3 / 3 | Ongoing grants |
| 50 / 25 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 38 / 19 | Completed scholarships in Brazil |
| 4 / 3 | Completed scholarships abroad |
| 98 / 53 | All research grants and scholarships |
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