| Full text | |
| Author(s): |
de Oliveira, Amanda Ribeiro
[1, 2]
;
Colombo, Ana Caroline
[1, 2]
;
Muthuraju, Sangu
[1, 2]
;
Almada, Rafael Carvalho
[1, 2]
;
Brandao, Marcus Lira
[1, 2]
Total Authors: 5
|
| Affiliation: | [1] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Lab Neuropsicofarmacol, Ribeirao Preto, SP - Brazil
[2] INeC, Ribeirao Preto, SP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | PLoS One; v. 9, n. 8 AUG 18 2014. |
| Web of Science Citations: | 9 |
| Abstract | |
Background: A reduction of dopamine release or D-2 receptor blockade in the terminal fields of the mesolimbic system clearly reduces conditioned fear. Injections of haloperidol, a preferential D-2 receptor antagonist, into the inferior colliculus (IC) enhance the processing of unconditioned aversive information. However, a clear characterization of the interplay of D-2 receptors in the mediation of unconditioned and conditioned fear is still lacking. Methods: The present study investigated the effects of intra-IC injections of the D-2 receptor-selective antagonist sulpiride on behavior in the elevated plus maze (EPM), auditory-evoked potentials (AEPs) to loud sounds recorded from the IC, fear-potentiated startle (FPS), and conditioned freezing. Results: Intra-IC injections of sulpiride caused clear proaversive effects in the EPM and enhanced AEPs induced by loud auditory stimuli. Intra-IC sulpiride administration did not affect FPS or conditioned freezing. Conclusions: Dopamine D-2-like receptors of the inferior colliculus play a role in the modulation of unconditioned aversive information but not in the fear-potentiated startle response. (AU) | |
| FAPESP's process: | 11/00041-3 - Neurobiology of stress: the sensorimotor gating |
| Grantee: | Marcus Lira Brandão |
| Support Opportunities: | Research Projects - Thematic Grants |