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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Pyridostigmine Restores Cardiac Autonomic Balance after Small Myocardial Infarction in Mice

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Durand, Marina T. [1] ; Becari, Christiane [1] ; de Oliveira, Mauro [1] ; do Carmo, Jussara M. [2] ; Aguiar Silva, Carlos Alberto [1] ; Prado, Cibele M. [3] ; Fazan, Jr., Rubens [1] ; Salgado, Helio C. [1]
Total Authors: 8
[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Physiol, Ribeirao Preto, SP - Brazil
[2] Univ Mississippi, Med Ctr, Dept Physiol & Biophys, Jackson, MS 39216 - USA
[3] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Pathol, Ribeirao Preto, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: PLoS One; v. 9, n. 8 AUG 18 2014.
Web of Science Citations: 9

The effect of pyridostigmine (PYR) - an acetylcholinesterase inhibitor - on hemodynamics and cardiac autonomic control, was never studied in conscious myocardial infarcted mice. Telemetry transmitters were implanted into the carotid artery under isoflurane anesthesia. Seven to ten days after recovery from the surgery, basal arterial pressure and heart rate were recorded, while parasympathetic and sympathetic tone (Delta HR) was evaluated by means of methyl atropine and propranolol. After the basal hemodynamic recording the mice were subjected to left coronary artery ligation for producing myocardial infarction (MI), or sham operation, and implantation of minipumps filled with PYR or saline. Separate groups of anesthetized (isoflurane) mice previously (4 weeks) subjected to MI, or sham coronary artery ligation, were submitted to cardiac function examination. The mice exhibited an infarct length of approximately 12%, no change in arterial pressure and increased heart rate only in the 1st week after MI. Vagal tone decreased in the 1 st week, while the sympathetic tone was increased in the 1 st and 4 th week after MI. PYR prevented the increase in heart rate but did not affect the arterial pressure. Moreover, PYR prevented the increase in sympathetic tone throughout the 4 weeks. Concerning the parasympathetic tone, PYR not only impaired its attenuation in the 1 st week, but enhanced it in the 4 th week. MI decreased ejection fraction and increased diastolic and systolic volume. Therefore, the pharmacological increase of peripheral acetylcholine availability by means of PYR prevented tachycardia, increased parasympathetic and decreased sympathetic tone after MI in mice. (AU)

FAPESP's process: 12/03349-1 - Effects of acetylcholinesterase blockade, central and peripheral, in the cardiocirculatory function and inflammation observed in spontaneously hypertensive rats
Grantee:Helio Cesar Salgado
Support Opportunities: Regular Research Grants