| Full text | |
| Author(s): |
Grotti Clemente, Ana Paula
[1]
;
da Luz Santos, Carla Danusa
[2]
;
Martins, Vinicius J. B.
[3]
;
Albuquerque, Maria Paula
[3]
;
Fachim, Mariana B.
[2]
;
Sawaya, Ana Lydia
[4]
Total Authors: 6
|
| Affiliation: | [1] Univ Fed Alagoas UFAL, Maceio, AL - Brazil
[2] Univ Fed Sao Paulo, UNIFESP, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Programa Posgrad Endocrinol Clin, UNIFESP, Sao Paulo - Brazil
[4] Univ Fed Sao Paulo, UNIFESP, Dept Fisiol, Sao Paulo - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | Jornal de Pediatria; v. 90, n. 5, p. 479-485, SEP-OCT 2014. |
| Web of Science Citations: | 0 |
| Abstract | |
Objective:Augmented waist circumference (WC) is associated with non-communicable diseases and could represent a valuable marker in screening for metabolic dysfunctions in subjects with insufficient linear growth. The objective of the present study was to determine whether bio-chemical and hemodynamic parameters and waist circumference vary between mildly-stunted and non-stunted adolescents from impoverished communities of São Paulo, Brazil.Methods:The cross-sectional study involved 206 subjects, aged between 9 and 19 years and living in impoverished areas of São Paulo, Brazil. The sample population was divided according to height-for-age Z-score (HAZ) into stunted (−1 > HAZ ≥ −2) and non-stunted (HAZ ≥ −1) groups, and was sub-divided according to gender. Logistic regression analysis was employed to compare individuals with elevated (> 75thpercentile) insulin concentrations. The receiver operating characteristic curves were constructed to determine WC cut-off points that could be used to identify stunted and non-stunted individuals with elevated insulin concentrations.Results:WC cut-off points of 58.25 cm and 67.2 cm allowed for correct classification of 90.7% of stunted and 88.7% of non-stunted individuals in the studied population. While the sensitivity of the model was high for stunted and non-stunted subjects (98.8% and 97.2%, respectively), the specificity was modest (57.1% and 41.2%, respectively).Conclusion:The results presented herein suggest that an increase in plasma insulin is one of the primary metabolic modifications in stunted individuals, and that this alteration could be identified at a lower WC cut-off point than in non-stunted counterparts. (AU) | |