Sleep deprivation impairs the extinction of cocaine-induced environmental conditioning in mice

Author(s):Show less -

Berro, L. F. ^[1] ; Hollais, A. W. ^[2] ; Patti, C. L. ^[1] ; Fukushiro, D. F. ^[2] ; Mari-Kawamoto, E. ^[2] ; Talhati, F. ^[2] ; Costa, J. M. ^[2] ; Zanin, K. A. ^[1] ; Lopes-Silva, L. B. ^[1] ; Ceccon, L. M. ^[2] ; Santos, R. ^[2] ; Procopio-Souza, R. ^[2] ; Trombin, T. F. ^[2] ; Yokoyama, T. S. ^[2] ; Wuo-Silva, R. ^[2] ; Tufik, S. ^[1] ; Andersen, M. L. ^[1] ; Frussa-Filho, R. ^{[1, 2]}

Affiliation

^[1] Univ Fed Sao Paulo, Dept Psychobiol, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Dept Pharmacol, Sao Paulo - Brazil

• Document type: Journal article
• Source: Pharmacology Biochemistry and Behavior; v. 124, p. 13-18, SEP 2014.
• Web of Science Citations: 10

Abstract

Persistence of a drug-environment conditioning induced by repeated psychostimulant treatment is thought to play a key role in the addictive cycle. In addition, sleep disorders are a common feature in patients with addictive disorders. Sleep deprivation shares similar neurobiological effects with psychostimulants. Therefore, we investigated whether sleep deprivation would impair the extinction of previously established conditioning between the drug effect and the environmental cues. Four cohorts of male adult mice underwent a behavioral sensitization procedure pairing drug (cocaine at 15 mg/kg, i.p.) or saline with environment (open-field apparatus). The extinction of conditioned locomotion was evaluated after control (home-cage maintained) or sleep deprivation (gentle handling method for 6 h) conditions. Sleep deprivation both postponed the initiation and impaired the completeness of extinction of the conditioned locomotion promoted by previous drug-environment conditioning in cocaine-sensitized animals. While the cocaine control group required 5 free-drug sessions of exposure to the open-field apparatus to complete extinction of conditioned locomotion, the cocaine pre-treated group that experienced sleep deprivation before each extinction session still significantly differed from its respective control group on Day 5 of extinction. The possibility that the sleep condition can influence the extinction of a long-lasting association between drug effects and environmental cues can represent new outcomes for clinically relevant phenomena. (C) 2014 Elsevier Inc. All rights reserved. (AU)

• FAPESP's process: 11/16580-0 - Effects of different stressors on addiction extinction and reinstatement in animal models
• Grantee: Laís Fernanda Berro
• Support Opportunities: Scholarships in Brazil - Master