Diffusion abnormalities of the corpus callosum in patients with malformations of cortical development and epilepsy

Author(s)

Andrade, Ceti S. ^{[1, 2]} ; Leite, Claudia C. ^[1] ; Otaduy, Maria C. G. ^[1] ; Lyra, Katarina P. ^[1] ; Valente, Kette D. R. ^[3] ; Yasuda, Clarissa L. ^{[4, 2]} ; Beltramini, Guilherme C. ^[4] ; Beaulieu, Christian ^[5] ; Gross, Donald W. ^[2]

Affiliation

^[1] Univ Sao Paulo, Dept Radiol, Sao Paulo - Brazil

^[2] Univ Alberta, Dept Med, Div Neurol, Edmonton, AB - Canada

^[3] Univ Sao Paulo, Dept Psychiat, Sao Paulo - Brazil

^[4] Univ Estadual Campinas, Dept Neurol, Sao Paulo - Brazil

^[5] Univ Alberta, Dept Biomed Engn, Edmonton, AB - Canada

• Document type: Journal article
• Source: Epilepsy Research; v. 108, n. 9, p. 1533-1542, NOV 2014.
• Web of Science Citations: 10

Abstract

Purpose: Diffusion tensor imaging (DTI) is a magnetic resonance imaging (MRI) technique that can characterize white matter (WM) architecture and microstructure. DTI has demonstrated extensive WM changes in patients with several epileptic syndromes, but few studies have focused on patients with malformations of cortical development (MCD). Our aim was to investigate the quantitative diffusion properties of the corpus callosum (CC), a major commissural bundle critical in inter-hemispheric connectivity, in a large group of patients with MCD. Methods: Thirty-two MCD patients and 32 age and sex-matched control subjects were evaluated with DTI at 3.0 T. We analyzed the three major subdivisions of the CC (genu, body, and splenium) with deterministic tractography to yield fractional anisotropy (FA), mean diffusivity (MD), parallel diffusivity (lambda parallel to) and perpendicular diffusivity (lambda perpendicular to). We further assessed the CC with region of interest (ROI)-based analyses and evaluated different subgroups of MCD (polymicrogyria/schizencephaly, heterotopia, and cortical dysplasia). Partial correlations between diffusion changes and clinical parameters (epilepsy duration and age at disease onset) were also queried. Results: There were significant reductions of FA, accompanied by increases in MD and lambda perpendicular to in all segments of the CC in the patients group with both analytical methods. The absolute differences in FA were greater on ROI-analyses. There were no significant differences between the MCD subgroups, and no correlations between clinical parameters of epilepsy and FA. Conclusions: Our study indicates DTI abnormalities consistent with microstructural changes in the corpus callosum of MCD patients. The findings support the idea that patients with epilepsy secondary to cortical malformations present widespread WM changes that extend beyond the macroscopic MRI-visible lesions. (C) 2014 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 12/00398-1 - White Matter Evaluation with Diffusion Magnetic Resonance Imaging Techniques at High Field Strength and Multiparametric Correlation with Volumetry and Phosphorus Spectroscopy in Patients with Epilepsy and Malformations of Cortical Development
• Grantee: Celi Santos Andrade
• Support type: Scholarships in Brazil - Post-Doctorate
• FAPESP's process: 05/56464-9 - Neuroscience Imaging Center at University of São Paulo Medical School
• Grantee: Giovanni Guido Cerri
• Support type: Inter-institutional Cooperation in Support of Brain Research (CINAPCE) - Thematic Grants