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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of age on aerobic capacity in heart failure patients under beta-blocker therapy: Possible impact in clinical decision-making?

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Author(s):
Ciolac, Emmanuel Gomes [1] ; Bocchi, Edimar Alcides [2] ; Fernandes da Silva, Miguel Morita [2] ; Tavares, Aline Cristina [2] ; Teixeira-Neto, Iram Soares [2] ; Guimaraes, Guilherme Veiga [2]
Total Authors: 6
Affiliation:
[1] Sao Paulo State Univ, UNESP, Sch Sci, Exercise & Chron Dis Res Lab, Phys Educ Dept, Bauru - Brazil
[2] Univ Sao Paulo, Hosp Clin, Fac Med, Heart Inst InCor, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: CARDIOLOGY JOURNAL; v. 20, n. 6, p. 655-661, 2013.
Web of Science Citations: 4
Abstract

Background: Heart failure (HF) is associated with impaired maximal aerobic capacity as indicated by decreases in peak oxygen uptake (peak VO2). Considering that aging by itself has a negative effect on this variable, the evaluation of maximum capacity is often questioned because current predicted peak VO2 is based on subjects without heart disease or beta-blocker therapy. In contrast, if decline in predicted and attained peak VO2 were age-related, proportionally, loss of aerobic function (predicted peak VO2, %) would remain stable over time in these patients. The purpose of this investigation is to assess the effects of age on peak VO2 in HF patients taking beta-blockers. Methods: We retrospectively evaluated 483 (132 female) patients (aged 20-88 years, LVEF 31 +/- 11%) with non-ischemic (n = 362), ischemic (n = 74) and Chagas-related HF (n = 47) who had been submitted to an incremental cardiopulmonary exercise testing on a motorized treadmill. Linear regression was used to develop the equation to predict peak VO2, based on age. Results: Peak VO2 decreased 0.9 mL/min/kg per age-decade, maximum HR also decreased with aging and VE/VCO2 slope was similar among all decades. The predicted new beta-blocker equation to peak VO2bb was 20.934 - 0.092 x age. Conclusions: Clinical interpretation of aerobic capacity impairment is influenced by aging in HF patients. This evidence must be considered when using peak VO2 for prognostic stratification and clinical decision-making in patients with HF under beta-blocker therapy. (AU)

FAPESP's process: 12/02409-0 - Effects of water based vs. land based exercise training on bone mass, physical fitness and body composition of heart transplant recipients
Grantee:Emmanuel Gomes Ciolac
Support Opportunities: Regular Research Grants