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| Author(s): |
Denicar Lina Nascimento Fabris
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2014-07-15 |
| Examining board members: |
Luis Carlos de Souza Ferreira;
Claudio Romero Farias Marinho;
Daniela Santoro Rosa
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| Advisor: | Luis Carlos de Souza Ferreira |
| Abstract | |
The heat-labile toxin (LT) produced by enterotoxigenic Escherichia coli (ETEC) are an important adjuvants to focus on academic and applied research, however little is known about the ability of these adjuvants to induce different patterns of glycosylation in IgG antibodies. Thus, the aim of this study was to analyze the ability of the adjuvants LT1 and its nontoxic derivative (LT1-K63 and LT1-B) influence on the quality of the humoral immune response, particularly regarding the glycosylation profiles of the EIII-specific IgG antibodies. The management of transmission lines provided potentiation response of antigen-specific antibodies modulate the profile of IgG subclasses, improved ability to induce virus neutralizing and different glycosylation profiles of in the antibodies purified IgG. The results demonstrate the importance of adjuvants in glycosylation of antigen-specific antibody profile and suggest the influence of glycosylation on the functionality of these antibodies. (AU) | |
| FAPESP's process: | 11/12751-5 - Adjuvant effects of Escherichia coli thermo-labile toxin (LT1) derivatives in the specific antibody response directed to the E glycoprotein domain III of type 2 dengue virus (DENV2). |
| Grantee: | Denicar Lina Nascimento Fabris |
| Support Opportunities: | Scholarships in Brazil - Master |