Fc gamma RIIa and Fc gamma RIIIb polymorphisms and associations with clinical manifestations in systemic lupus erythematosus patients

Author(s)

Costa Vigato-Ferreira, Isabel Cristina ^[1] ; Toller-Kawahisa, Juliana Escher ^[2] ; Tres Pancoto, Joao Alexandre ^[3] ; Mendes-Junior, Celso Teixeira ^[4] ; Martinez, Edson Zangiacomi ^[5] ; Donadi, Eduardo Antonio ^[6] ; Louzada-Junior, Paulo ^[6] ; Cavalcanti Del Lama, Jose Eduardo ^[1] ; Marzocchi-Machado, Cleni Mara ^[1]

Affiliation

^[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, BR-14040903 Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Fac Med Ribeirao Preto, BR-14040903 Ribeirao Preto, SP - Brazil

^[3] Univ Fed Espirito Santo, Dept Ciencias Saude, Sao Mateus, ES - Brazil

^[4] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, BR-14040903 Ribeirao Preto, SP - Brazil

^[5] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Social Med, BR-14040903 Ribeirao Preto, SP - Brazil

^[6] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Clin Med, BR-14040903 Ribeirao Preto, SP - Brazil

• Document type: Journal article
• Source: AUTOIMMUNITY; v. 47, n. 7, p. 451-458, NOV 2014.
• Web of Science Citations: 7

Abstract

In this study, we aimed to investigate whether the distribution of the Fc gamma RIIa and Fc gamma RIIIb polymorphisms determines susceptibility to systemic lupus erythematosus (SLE) and acts as predictors of SLE clinical manifestations in the Brazilian patients. A total of 157 patients that fulfilled the American College of Rheumatology classification criteria for SLE and 160 healthy volunteers were included in this study. FCGR2A and FCGR3B genotypes were determined by polymerase chain reaction-based allotyping methods with allele-specific primers; the clinical features were obtained from the patients' official medical records. In the case of Fc gamma RIIa polymorphism, it was observed association of the allele FCGR2A-R-131 (p = 0.02, odds ratio (OR) = 1.44) and genotype RR-131 (p = 0.03, OR = 2.09) with SLE. These associations were higher with allele (p<0.01, OR = 1.67) as well genotype (p = 0.01, OR = 2.85) when lupus nephritis was considered. In contrast, the allele FCGR2A-H-131 was associated with susceptibility to arthritis and anti-DNA antibodies (p = 0.05 for both). As for Fc gamma RIIIb polymorphism, skewing did not differ significantly between patients and controls, however the genotype FCGR3B{*}02{*}02 was associated with susceptibility to arthritis (p = 0.02) and malar rash (p = 0.03), but no association with nephritis was found. The results demonstrate that Fc gamma RIIa polymorphism is associated with susceptibility to SLE in Brazilian patients, whereas for Fc gamma RIIIb polymorphism no association was found. However, notably, both polymorphisms present allelic variants that influence the clinical manifestations and may contribute to the pathogenesis of the disease. In addition, to our knowledge, this is the first study considering the frequency of Fc gamma RIIIb polymorphism in Brazilian SLE patients. (AU)

• FAPESP's process: 09/12649-6 - Association of FcgammaR and CR3 polymorphisms with bacterial infections in systemic lupus erythematosus: determination of the genotype combinations and their influence on the oxidative burst of neutrophils
• Grantee: Juliana Escher Toller
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 09/14732-8 - Association of FcgammaR and CR3 polymorphisms with bacterial infections in systemic lupus erythematosus: determination of the genotype combinations and their influence on the neutrophil effector functions
• Grantee: Cleni Mara Marzocchi Machado
• Support Opportunities: Regular Research Grants