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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Solubility enhancement of ibuprofen using tri-ureasil-PPO hybrid: structural, cytotoxic, and drug release investigation

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Caravieri, Beatriz B. [1] ; de Oliveira, Pollyanna F. [1] ; Furtado, Ricardo A. [1] ; Tavares, Denise C. [1] ; Nassar, Eduardo J. [1] ; Ciuffi, Katia J. [1] ; Molina, Eduardo F. [1]
Total Authors: 7
[1] Univ Franca, Dept Chem, BR-14404600 Franca, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Journal of Sol-Gel Science and Technology; v. 72, n. 3, p. 627-636, DEC 2014.
Web of Science Citations: 3

Herein, we used tri-ureasil organic-inorganic hybrid material (tU5000) in order to enhance the solubility of nonsteroidal anti-inflammatory drugs and fine tuning the drug delivery profile. For the first time, we used tU5000 as a film-forming agent in order to provide an alternative vehicle for transdermal drug delivery systems which the cell viability of practically 100 % for the highest and the lowest tested concentrations of pure tU5000 indicated that the material was not cytotoxic. The physicochemical properties of the tU5000 drug carrier and drug-loaded hybrids were systematically studied using powder X-ray diffraction, differential scanning calorimetry, small-angle X-ray scattering, and Fourier-transform infrared spectroscopy. The structural changes of tU5000 as well as the relationships between the drug content and in vitro drug release behaviors were investigated. The results showed that the ibu molecules were homogeneously distributed in the tU5000 xerogels contributing to fine-tuning the drug delivery profile. Considering the ability to incorporated high drug content, simple and mild preparation procedure by one-pot sol-gel route, high stability of the materials, sustained-release property, this class of hybrid based on polymers and inorganic compounds may have potential applications in the design of pharmaceutical formulation as ophthalmic (contact lenses), transdermal (patches) and implantable (soft tissue) drug delivery systems. (AU)

FAPESP's process: 13/02613-0 - Multifunctional organic-inorganic hybrids siloxane-polyether used as drug delivery systems.
Grantee:Beatriz Bernardes Caravieri
Support type: Scholarships in Brazil - Scientific Initiation