e-polycaprolactone and D-±-tocopherol polyethylene glycol-1000 nanoparticles containing docetaxel aiming prostate cancer therapy

• Grant number: 16/03013-4
• Support Opportunities: Scholarships in Brazil - Master
• Start date: August 01, 2016
• End date: February 28, 2018
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Juliana Maldonado Marchetti
• Grantee: Giovanni Loureiro Raspantini
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Prostate cancer is the second most incident type of cancer among men. Only in Brazil, 61.200 new cases are expected to be diagnosed in 2016. Though a huge progress has been observed on the prostate cancer treatment over the last few decades, this pathology keeps being the second highest cause of deaths related to cancer among men. Regarding the indicated drugs for the treatment of this pathology, docetaxel appears as the first choice considering its effectiveness on therapeutics. However, many adverse effects are related to its use - such as neutropenia. The delivery of anticancer drugs from nanostructured delivery systems has been broadly studied, given the several benefits they offer: higher solubility, stability, enhanced permeability and retention (EPR effect) at the tumor site, allowing reduction in the number of administrations and side effects. Within this context, the present work aims to develop and characterize polymeric nanoparticles synthesized using -polycaprolactone and D-±-tocopherol polyethylene glycol-1000 loaded with docetaxel for prostate cancer therapy. The nanoparticles will be obtained by the nanoprecipitation technique and assessed for their physicochemical properties (size, zeta potential, polydispersity, morphology, entrapment efficiency, thermal properties, FTIR spectroscopy absorption profile, and in vitro release profile). The evaluation will be perfomed in vitro, thorugh the study of cell uptake by confocal microscopy and flow cytometry, besides the investigation of the cytotoxicity against prostate cancer cell lines.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RASPANTINI, GIOVANNI LOUREIRO; LUIZ, MARCELA TAVARES; ABRIATA, JULIANA PALMA; ELOY, JOSIMAR DE OLIVEIRA; VAIDERGORN, MIGUEL MENEZES; DA SILVA EMERY, FLAVIO; MARCHETTI, JULIANA MALDONADO. PCL-TPGS polymeric nanoparticles for docetaxel delivery to prostate cancer: Development, physicochemical and biological characterization. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v. 627, OCT 20 2021. (16/03013-4, 17/04091-1)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

RASPANTINI, Giovanni Loureiro. Development and characterization of PCL-TPGS nanoparticles carrying docetaxel aiming prostate cancer therapy. 2018. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (PCARP/BC) Ribeirão Preto.