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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Highly Efficient and Magnetically Recoverable Niobium Nanocatalyst for the Multicomponent Biginelli Reaction

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Author(s):
Lima, Carolina G. S. [1] ; Silva, Sandrina [1] ; Goncalves, Ricardo H. [1] ; Leite, Edson R. [1] ; Schwab, Ricardo S. [1] ; Correa, Arlene G. [1] ; Paixao, Marcio W. [1]
Total Authors: 7
Affiliation:
[1] Univ Fed Sao Carlos, Dept Chem, BR-13565905 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: CHEMCATCHEM; v. 6, n. 12, p. 3455-3463, DEC 2014.
Web of Science Citations: 24
Abstract

A new magnetically recoverable nanocatalyst was prepared by coating magnetite with niobium oxide (Fe3O4@Nb2O5) by using a simple wet impregnation method. The Fe3O4@Nb2O5 nanocatalyst was fully characterized, and its catalytic activity was evaluated by using the one-pot, three-component Biginelli reaction, with the aim to synthesize 1,4-dihydropyrimidinones, a class of compounds with diverse pharmacological properties. The developed protocol was applied to a wide range of aliphatic and aromatic substrates, and structurally diverse products were obtained in excellent yields. Compared with copper and nickel nanocatalysts, the Fe3O4@Nb2O5 nanocatalyst demonstrated superior catalytic activity at a remarkably low catalyst loading (0.1 mol%). This niobium nanocatalyst could be easily separated from the reaction mixture with an external magnet and was reused several times without any loss of its catalytic activity. Moreover, although the Biginelli reaction is a century-old reaction, its mechanism is still a controversial subject, and our investigation provided an insight into the reaction mechanism. (AU)

FAPESP's process: 09/07281-0 - Asymmetric organocatalysis: design of new organocatalysts and development of new methodologies
Grantee:Márcio Weber Paixão
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 12/04986-5 - Asymmetric organocatalysis: development of new methodologies and application in total synthesis
Grantee:Sandrina Isabel Ribeiro Martins da Silva
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 13/06558-3 - Asymmetric catalysis: preparation of chiral alcohols and their derivatives from highly functionalized organozinc reagents and application of new chiral ligands supported on magnetic nanoparticles
Grantee:Ricardo Samuel Schwab
Support type: Regular Research Grants