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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cannabidiol and endogenous opioid peptide-mediated mechanisms modulate antinociception induced by transcutaneous electrostimulation of the peripheral nervous system

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Author(s):
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Teixeira Goncalves, Thais Cristina [1] ; Londe, Anna Karla [1] ; Pires Albano, Rafael Isaac [2] ; de Araujo Junior, Artur Teixeira [3] ; Azeredo, Mariana de Aguiar [2] ; Biagioni, Audrey Francisco [2] ; Ferreira Vasconcellos, Thiago Henrique [4] ; dos Reis Ferreira, Celio Marcos [5] ; Teixeira, Dulcinea Goncalves [6] ; de Souza Crippa, Jose Alexandre [7] ; Vieira, Debora [1] ; Coimbra, Norberto Cysne [2]
Total Authors: 12
Affiliation:
[1] Patos de Minas Ctr Univ UNIPAM, Sch Med, Lab Physiol & Biophys, Dept Med, BR-38702054 Patos De Minas, MG - Brazil
[2] Univ Sao Paulo, Lab Neuroanat & Neuropsychobiol, Dept Pharmacol, Ribeirao Preto Med Sch, BR-14049900 Ribeirao Preto, SP - Brazil
[3] Fed Univ Rio Grande Sul UFRGS, Sch Biotechnol, Dept Biotechnol, Lab Signaling & Cell Plast, BR-91501970 Bento Goncalves, RS - Brazil
[4] Patos de Minas Ctr Univ UNIPAM, Sch Med, Dept Psychol, Psychol Lab, BR-38702054 Patos De Minas, MG - Brazil
[5] Fed Univ Jequitinhonha & Mucuri Valleys UFVJM, Sch Biol & Hlth Sci, Dept Physiotherapy, Lab Clin Physiotherapy, BR-39100000 Diamantina, MG - Brazil
[6] Patos de Minas Ctr Univ UNIPAM, Dept Human Anat, Anat Lab, Sch Med, BR-38702054 Patos De Minas, MG - Brazil
[7] Univ Sao Paulo, Div Psychiat, Dept Neurosci & Behav Sci, Ribeirao Preto Med Sch, BR-14049900 Ribeirao Preto, SP - Brazil
Total Affiliations: 7
Document type: Journal article
Source: JOURNAL OF THE NEUROLOGICAL SCIENCES; v. 347, n. 1-2, p. 82-89, DEC 15 2014.
Web of Science Citations: 5
Abstract

Transcutaneous electrical nerve stimulation (TENS) is a non-pharmacological therapy for the treatment of pain. The present work investigated the effect of cannabidiol, naloxone and diazepam in combination with 10 Hz and 150 Hz TENS. Male Wistar rats were submitted to the tail-flick test (baseline), and each rodent received an acute administration (intraperitoneal) of naloxone (3.0 mg/kg), diazepam (1.5 mg/kg) or cannabidiol (0.75 mg/kg, 1.5 mg/kg, 3.0 mg/kg, 4.5 mg/kg, 6.0 mg/kg and 12.0 mg/kg); 10 min after the acute administration, 10 Hz or 150 Hz TENS or a sham procedure was performed for 30 min. Subsequently, tail-flick measures were recorded over a 90-min period, at 5-min intervals. 10 Hz TENS increased the nociceptive threshold during the 90-min period. This antinociceptive effect was reversed by naloxone pre-treatment, was not altered by diazepam pretreatment and was abolished by cannabidiol pre-treatment (1.5 mg/kg). Moreover, 150 Hz TENS increased tail-flick latencies by 35 min post-treatment, which was partially inhibited by naloxone pre-treatment and totally inhibited by cannabidiol (1.5 mg/kg). These data suggest the involvement of the endogenous opioid system and the cannabinoid-mediated neuromodulation of the antinociception induced by transcutaneous electrostimulation at 10 Hz and 150 Hz TENS. (C) 2014 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 07/01174-1 - Study of the Involvement of opioid-, serotonergic- and noradrenergic-mechanisms of the pain endogenous inhibitory system in antinociceptive processes induced by oriented escape reactions evoked by chemical stimulation of the merdial hypothalamus
Grantee:Norberto Cysne Coimbra
Support Opportunities: Regular Research Grants
FAPESP's process: 08/08955-1 - Involvement of the Dorsal Raphe Nucleus Neural Networks and Serotonergic Neurotransmittion in the Locus Coeruleus in Antinociceptive Processess Induced by Oriented Escape Reaction Evoked by Chemical Stimulation of the Medial Hypothalamus.
Grantee:Audrey Franceschi Biagioni
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 12/03798-0 - Involvement of opioid and endocanabinoid receptors of the substantia nigra on the activity of Nigro-Tectal GABAergic pathways during defensive behaviour elicited by rodents confronted with venomous snakes
Grantee:Norberto Cysne Coimbra
Support Opportunities: Regular Research Grants