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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Deep brain stimulation of the inferior colliculus: A possible animal model to study paradoxical kinesia observed in some parkinsonian patients?

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Author(s):
Melo-Thomas, Liana [1, 2, 3] ; Thomas, Uwe [4]
Total Authors: 2
Affiliation:
[1] Univ Fed Sao Paulo, Dept Biociencias, BR-11060001 Santos, SP - Brazil
[2] INEC, Inst Neurociencias & Comportamento, BR-14050220 Ribeirao Preto, SP - Brazil
[3] Univ Marburg, D-35032 Marburg - Germany
[4] Thomas RECORDING GmbH, D-35394 Giessen - Germany
Total Affiliations: 4
Document type: Journal article
Source: Behavioural Brain Research; v. 279, p. 1-8, FEB 15 2015.
Web of Science Citations: 9
Abstract

The inferior colliculus (IC) plays an important role in the normal processing of the acoustic message and is also involved in the filtering of acoustic stimuli of aversive nature. The neural substrate of the IC can also influence haloperidol-induced catalepsy. Considering that (i) paradoxical kinesia, observed in some parkinsonian patients, seems to be dependent of their emotional state and (ii) deep brain stimulation (DBS) represents an alternative therapeutic route for the relief of parkinsonian symptoms, the present study investigated the consequence of DBS at the IC on the catalepsy induced by haloperidol in rats. Additionally, we investigated if DBS of the IC can elicit motor responses in anesthetized rats and whether DBS elicits distinct neural firing patterns of activity at the dorsal cortex (DCIC) or central nucleus (CNIC) of the IC. A significant reduction of the catalepsy response was seen in rats previously given haloperidol and receiving DBS at the IC. In addition, electrical stimulation to the ventral part of the CNIC induced immediate motor responses in anesthetized rats. The neuronal spontaneous activity was higher at the ventral part of the CNIC than the dorsal part. DBS to the ventral part but not to the dorsal part of the CNIC increased the spike rate at neurons a few hundred microns away from the stimulation site. It is possible that the IC plays a role in the sensorimotor gating activated by emotional stimuli, and that DBS at the IC can be a promising new animal model to study paradoxical kinesia in rats. (C) 2014 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 11/01409-4 - Electrical stimulation and recording of the neural activity into the inferior colliculus during the haloperidol-induced catalepsy: a behavioral and electrophysiologic study
Grantee:Liana Melo-Thomas
Support Opportunities: Regular Research Grants