Evaluation of mutagenic activity of Ruthenium(II)heteroleptic complexe with anti- ...
| Full text | |
| Author(s): |
Barbosa, Marilia I. F.
[1]
;
Correa, Rodrigo S.
[1]
;
Pozzi, Lucas V.
[1]
;
Lopes, Erica de O.
[2]
;
Pavan, Fernando R.
[2]
;
Leite, Clarice Q. F.
[2]
;
Ellena, Javier
[3]
;
Machado, Sergio de P.
[4]
;
Von Poelhsitz, Gustavo
[5]
;
Batista, Alzir A.
[1]
Total Authors: 10
|
| Affiliation: | [1] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil
[2] Univ Estadual Paulista, Dept Ciencias Biol, Fac Ciencias Farmaceut, BR-14800900 Araraquara, SP - Brazil
[3] Univ Sao Paulo, Inst Fis Sao Carlos, BR-13560970 Sao Carlos, SP - Brazil
[4] Univ Fed Rio de Janeiro, Inst Quim, BR-21941590 Rio De Janeiro, RJ - Brazil
[5] Univ Fed Uberlandia, Inst Quim, BR-38400902 Uberlandia, MG - Brazil
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | Polyhedron; v. 85, p. 376-382, JAN 8 2015. |
| Web of Science Citations: | 17 |
| Abstract | |
Three promising antimycobacterium tuberculosis ruthenium(II) complexes with the deprotonated ligands 2-hydroxynicotinic acid (2-OHnicH), 6-hydroxynicotinic acid (6-OHnicH) and 3-hydroxypicolinic acid (3-OHpicH) were synthesized and characterized. Structural analysis revealed three different coordination modes depending of the hydroxypyridinecarboxylate ligand. In the complex {[}Ru(2-OHnic)(dppb)(bipy)PF6 (1), the 2-OHnic anion is coordinated by the O,O-chelating mode (via carboxylate group and phenolate oxygen), in the Ru(6-OHnic)(dppb)(bipy)]PF6 (2) a O-O chelation by the carboxylate group is observed for the 6-OHnic ligand and for the complex {[}Ru(3-OHpic)(dppb)(bipy))PF6 (3) a N,O-chelating mode (via carboxylate) occurs to the 3-OHpic anion. The compounds were evaluated for activity against Mycobacterium tuberculosis H(37)Rv ATCC 27294 using Resazurin Microtitre Assay (REMA) plate method and cytotoxicity in VERO CCL-81 cell line. All the synthesized compounds exhibited good antimycobacterial activity and a completely lack of cytotoxicity activity, indicating a good selectivity index. (C) 2014 Elsevier Ltd. All rights reserved. (AU) | |
| FAPESP's process: | 13/26559-4 - Structural modifications in biologically active Ru(II) complexes toward the design of new metallodrug candidates |
| Grantee: | Rodrigo de Souza Corrêa |
| Support type: | Scholarships in Brazil - Post-Doctorate |