| Full text | |
| Author(s): |
Total Authors: 3
|
| Affiliation: | [1] Maua Inst Technol IMT, BR-09580900 Sao Caetano do Sul, SP - Brazil
[2] Univ Campinas UNICAMP, Sch Chem Engn, Campinas, SP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | Powder Technology; v. 269, p. 185-192, JAN 2015. |
| Web of Science Citations: | 7 |
| Abstract | |
In this work, didofenac sodium pellets were produced through an extrusion/spheronization process and subsequently coated in a fluidized bed coater column with a Wurster insert. The aim of this work was to study the coating of pellets with two commercial aqueous enteric polymer suspensions, Advantia (R) Performance and Acryl-Eze (R) MP. The coating process was studied with a 2(3) experimental design. The variables were as follows: inlet air temperature, suspension flow rate and coating polymer. The response variables were as follows: the process efficiency, which generated results above 782%, and the agglomeration fraction, which generated results below 8%. The polymer coating type was the variable that influenced the response variables the most. The minimum masses gain needed to achieve enteric release were also determined: Actyl-Eze (R) MP: 9.7% and Advantia (R) Performance: 8.6%. The coated pellets were tested for drug content, dissolution and stability. Neither the drug content nor the release profiles were significantly affected by storage at 40 degrees C and 75%. The suspensions were tested for rheology, contact angle and static wettability to investigate the characteristics of the polymer. (C) 2014 Elsevier B.V. All rights reserved. (AU) | |
| FAPESP's process: | 09/11834-4 - Comparison of diferents commercial polimers used in coating of controled release pellets |
| Grantee: | Roberta Albanez Toreta |
| Support Opportunities: | Scholarships in Brazil - Master |