| Full text | |
| Author(s): |
Total Authors: 2
|
| Affiliation: | [1] Univ Sao Paulo, Inst Trop Med Sao Paulo, Sao Paulo - Brazil
[2] Univ Fed Alagoas, Univ Hosp, Maceio, Alagoas - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | Revista do Instituto de Medicina Tropical de São Paulo; v. 57, n. 1, p. 1-13, JAN-FEB 2015. |
| Web of Science Citations: | 20 |
| Abstract | |
Human T-lymphotropic virus type 1 (HTLV-1) is found in indigenous peoples of the Pacific Islands and the Americas, whereas type 2 (HTLV-2) is widely distributed among the indigenous peoples of the Americas, where it appears to be more prevalent than HTLV-1, and in some tribes of Central Africa. HTLV-2 is considered ancestral in the Americas and is transmitted to the general population and injection drug users from the indigenous population. In the Americas, HTLV-1 has more than one origin, being brought by immigrants in the Paleolithic period through the Bering Strait, through slave trade during the colonial period, and through Japanese immigration from the early 20th century, whereas HTLV-2 was only brought by immigrants through the Bering Strait. The endemicity of HTLV-2 among the indigenous people of Brazil makes the Brazilian Amazon the largest endemic area in the world for its occurrence. A review of HTLV-1 in all Brazilian tribes supports the African origin of HTLV-1 in Brazil. The risk of hyperendemicity in these epidemiologically closed populations and transmission to other populations reinforces the importance of public health interventions for HTLV control, including the recognition of the infection among reportable diseases and events. (AU) | |
| FAPESP's process: | 12/23397-0 - Determination of IL28B polymorphism profile in patients co-infected with Chronic Hepatitis C (HCV) virus and human T-lymphotropic type 1 (HTLV-1) |
| Grantee: | Jorge Simao do Rosario Casseb |
| Support Opportunities: | Regular Research Grants |