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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Involvement of Major Components from Sporothrix schenckii Cell Wall in the Caspase-1 Activation, Nitric Oxide and Cytokines Production During Experimental Sporotrichosis

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Author(s):
Goncalves, Amanda Costa [1] ; Geraldo Maia, Danielle Cardoso [1] ; Ferreira, Lucas Souza [1] ; Silva Monnazzi, Luis Gustavo [1] ; Alegranci, Pamela [1] ; Polesi Placeres, Marisa Campos [1] ; Batista-Duharte, Alexander [1] ; Carlos, Iracilda Zeppone [1]
Total Authors: 8
Affiliation:
[1] Sao Paulo State Univ, Dept Clin Anal, Fac Pharmaceut Sci, BR-14801902 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Mycopathologia; v. 179, n. 1-2, p. 21-30, FEB 2015.
Web of Science Citations: 16
Abstract

Sporotrichosis is a chronic infection caused by the dimorphic fungus Sporothrix schenckii, involving all layers of skin and the subcutaneous tissue. The role of innate immune toll-like receptors 2 and 4 in the defense against this fungus has been reported, but so far, there were no studies on the effect of cell wall major components over the cytosolic oligo-merization domain (NOD)-like receptors, important regulators of inflammation and responsible for the maturation of IL-1 beta and IL-18, whose functions are dependents of the caspase-1 activation, that can participate of inflammasome. It was evaluated the percentage of activation of caspase-1, the production of IL-1 beta, IL-18, IL-17, IFN-gamma and nitric oxide in a Balb/c model of S. schenckii infection. It was observed a decreased activity of caspase-1 during the fourth and sixth weeks of infection accompanied by reduced secretion of the cytokines IL-1 beta, IL-18 and IL-17 and high production of nitric oxide. IFN-gamma levels were elevated during the entire time course of infection. This temporal reduction in caspase-1 activity coincides exactly with the reported period of fungal burden associated with a transitory immunosuppression induced by this fungus and detected in similar infection models. These results indicate the importance of interaction between caspase-1, cytokines IL-1 beta and IL-18 in the host defense against S. schenckii infection, suggesting a participation the inflammasome in this response. (AU)

FAPESP's process: 13/03190-5 - Role of the inflammasome in to fungal infections induced by Sporothrix schenckii
Grantee:Amanda Costa Gonçalves
Support Opportunities: Scholarships in Brazil - Doctorate