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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Community-associated methicillin-resistant Staphylococcus aureus in non-outbreak skin infections

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Author(s):
Bonesso, Mariana Favero [1, 2] ; Marques, Silvio Alencar [3] ; Camargo, Carlos Henrique [1] ; Castelo Branco Fortaleza, Carlos Magno [2] ; Ribeiro de Souza da Cunha, Maria de Lourdes [1]
Total Authors: 5
Affiliation:
[1] Univ Estadual Paulista, Dept Microbiol & Imunol, Inst Biociencias Botucatu, BR-18618970 Botucatu, SP - Brazil
[2] Univ Estadual Paulista, Fac Med Botucatu, Dept Doencas Trop, BR-18618970 Botucatu, SP - Brazil
[3] Univ Estadual Paulista, Fac Med Botucatu, Dept Dermatol & Radiol, BR-18618970 Botucatu, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Brazilian Journal of Microbiology; v. 45, n. 4, p. 1401-1407, OCT-DEC 2014.
Web of Science Citations: 7
Abstract

The aim of this study was to determine the prevalence of Staphylococcus aureus and risk factors for the acquisition of MRSA (Methicillin Resistant Staphylococcus aureus) as the main cause of skin and soft tissue infections. S. aureus were characterized for the presence of PVL, TSST-1 and mecA genes. SCCmec typing was carried out in mecA positive strains and PFGE was performed only in these strains. During the study period, 127 outpatients attending a dermatology clinical the Botucatu Medical School, a regional tertiary hospital in Botucatu, Sao Paulo, Brazil, were diagnosed with active skin infections. A total 66 (56.9%) S. aureus strains were isolated. The methicillin resistance gene mecA was detected in seven (10.6%) S. aureus strains. The SCCmec types detected in the seven mecA-positive S. aureus strains were type Ia in one, type II in three, and type IV in three. The PVL gene was detected in 10 (15.1%) in sensitive strains. Pulsed field gel electrophoresis revealed non-clonal diversity among the isolates. The risk factors associated with MRSA acquisition in this study were previous ciprofloxacin use and working in a healthcare environment. The risk factors indicate plausible routes of CA-MRSA transmission among the subjects studied. (AU)

FAPESP's process: 09/09569-0 - Determination of CA-MRSA and coagulase-negative Staphylococcus virulence and resistance isolated from Dermatology's patients from Hospital das Clínicas at Faculdade de Medicina de Botucatu, SP
Grantee:Maria de Lourdes Ribeiro de Souza da Cunha
Support Opportunities: Regular Research Grants