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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Involvement of non-NMDA glutamate receptors of the hypothalamic paraventricular nucleus in the cardiovascular response to the microinjection of noradrenaline into the dorsal periaqueductal gray area of rats

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Author(s):
Pelosi, Gislaine Garcia [1, 2] ; Busnardo, Cristiane [1] ; Tavares, Rodrigo Fiacadori [1] ; Aguiar Correa, Fernando Morgan [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Pharmacol, BR-14040900 Sao Paulo - Brazil
[2] Univ Estadual Londrina, Ctr Biol Sci, Dept Physiol Sci, Londrina, PR - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Brain Research; v. 1602, p. 96-105, MAR 30 2015.
Web of Science Citations: 0
Abstract

The dorsal periaqueductal gray area (dPAG) is involved in cardiovascular modulation. In a previous study, we showed that noradrenaline (NA) microinjected into the dPAG caused a vasopressin-mediated pressor response, involving a relay in the hypothalamic paraventricular nucleus (PVN). In the present study, we evaluated the involvement of ionotropic glutamate receptors within the PVN in the cardiovascular response to NA microinjection into the dPAG of unanesthetized rats. Microinjection of the selective NMDA glutamate receptor antagonist LY235959 (2 nmo1/100 nL) unilaterally into the PVN did not affect the cardiovascular response evoked by microinjection of NA (15 nmo1/50 nL) into the dPAG. On the other hand, unilateral PVN pretreatment with the non-NMDA glutamate receptor antagonist NBQX (2 nmoV100 nL) significantly reduced the pressor and cardiac response caused by microinjection of NA into the dPAG. In addition, bilateral PVN pretreatment with NBQX (2 nmoV100 nL) blocked the cardiovascular response to NA injected into the dPAG. In conclusion, the present results suggest that bilateral PVN activation of non-NMDA glutamate receptors mediates the vasopressin-related cardiovascular response to the microinjection of NA into the dPAG. (C) 2015 Elsevier B.V. All rights reserved. (AU)