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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Reduced Slc2a4/GLUT4 expression in subcutaneous adipose tissue of monosodium glutamate obese mice is recovered after atorvastatin treatment

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Author(s):
Poletto, Ana Claudia [1] ; David-Silva, Aline [1] ; de Melo Yamamoto, Aline Pedro [1] ; Machado, Ubiratan Fabres [1] ; Furuya, Daniela Tomie [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508900 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: DIABETOLOGY & METABOLIC SYNDROME; v. 7, MAR 14 2015.
Web of Science Citations: 12
Abstract

Background: Decreased expression of glucose transporter protein GLUT4, encoded by the solute carrier 2A4 (Slc2a4) gene, is involved in obesity-induced insulin resistance. Local tissue inflammation, by nuclear factor-kappa B (NF kappa B)-mediated pathway, has been related to Slc2a4 repression; a mechanism that could be modulated by statins. Using a model of obesity with insulin resistance, this study investigated whether (1) inflammatory markers and Slc2a4 expression are altered; (2) atorvastatin has beneficial effects on inflammation and Slc2a4 expression; and (3) inhibitor of NF kappa B (IKK)/NF kappa B pathway is involved in subcutaneous adipose tissue (SAT). Findings: Obese mice showed insulin resistance, decreased expression of Slc2a4 mRNA (66%, P < 0.01) and GLUT4 protein (30%, P < 0.05), and increased expression of interleukin 6 (Il6) mRNA (44%, P < 0.05) in SAT. Obese mice treated with atorvastatin had enhanced in vivo insulin sensitivity, besides increased Slc2a4/GLUT4 expression and reduced Il6 expression in SAT. No alterations of tumor necrosis factor-alpha, interleukin 1 beta and adiponectin expression or IKK alpha/beta activity in SAT of obese mice or obese mice treated with atorvastatin were observed. Conclusions: Atorvastatin has beneficial effect upon glycemic homeostasis, which may be related to its positive impact on Il6 and Slc2a4/GLUT4 expression in SAT. (AU)

FAPESP's process: 12/04831-1 - New players in glycemic control and chronic complications of Diabetes mellitus: preventive and therapeutic perspectives
Grantee:Ubiratan Fabres Machado
Support type: Research Projects - Thematic Grants
FAPESP's process: 14/10007-5 - Regulation of glucose metabolism by the bone: role of osteocalcin in insulin resistance and inflammation of adipose tissue and liver
Grantee:Daniela Tomie Furuya
Support type: Scholarships in Brazil - Young Researchers
FAPESP's process: 13/18841-1 - Regulation of glucose metabolism by the bone: role of osteocalcin in insulin resistance and inflammation of adipose tissue and liver
Grantee:Daniela Tomie Furuya
Support type: Research Grants - Young Investigators Grants