Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Reduced Slc2a4/GLUT4 expression in subcutaneous adipose tissue of monosodium glutamate obese mice is recovered after atorvastatin treatment

Full text
Author(s):
Poletto, Ana Claudia [1] ; David-Silva, Aline [1] ; de Melo Yamamoto, Aline Pedro [1] ; Machado, Ubiratan Fabres [1] ; Furuya, Daniela Tomie [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508900 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: DIABETOLOGY & METABOLIC SYNDROME; v. 7, MAR 14 2015.
Web of Science Citations: 12
Abstract

Background: Decreased expression of glucose transporter protein GLUT4, encoded by the solute carrier 2A4 (Slc2a4) gene, is involved in obesity-induced insulin resistance. Local tissue inflammation, by nuclear factor-kappa B (NF kappa B)-mediated pathway, has been related to Slc2a4 repression; a mechanism that could be modulated by statins. Using a model of obesity with insulin resistance, this study investigated whether (1) inflammatory markers and Slc2a4 expression are altered; (2) atorvastatin has beneficial effects on inflammation and Slc2a4 expression; and (3) inhibitor of NF kappa B (IKK)/NF kappa B pathway is involved in subcutaneous adipose tissue (SAT). Findings: Obese mice showed insulin resistance, decreased expression of Slc2a4 mRNA (66%, P < 0.01) and GLUT4 protein (30%, P < 0.05), and increased expression of interleukin 6 (Il6) mRNA (44%, P < 0.05) in SAT. Obese mice treated with atorvastatin had enhanced in vivo insulin sensitivity, besides increased Slc2a4/GLUT4 expression and reduced Il6 expression in SAT. No alterations of tumor necrosis factor-alpha, interleukin 1 beta and adiponectin expression or IKK alpha/beta activity in SAT of obese mice or obese mice treated with atorvastatin were observed. Conclusions: Atorvastatin has beneficial effect upon glycemic homeostasis, which may be related to its positive impact on Il6 and Slc2a4/GLUT4 expression in SAT. (AU)

FAPESP's process: 12/04831-1 - New players in glycemic control and chronic complications of Diabetes mellitus: preventive and therapeutic perspectives
Grantee:Ubiratan Fabres Machado
Support type: Research Projects - Thematic Grants
FAPESP's process: 14/10007-5 - Regulation of glucose metabolism by the bone: role of osteocalcin in insulin resistance and inflammation of adipose tissue and liver
Grantee:Daniela Tomie Furuya
Support type: Scholarships in Brazil - Young Researchers
FAPESP's process: 13/18841-1 - Regulation of glucose metabolism by the bone: role of osteocalcin in insulin resistance and inflammation of adipose tissue and liver
Grantee:Daniela Tomie Furuya
Support type: Research Grants - Young Investigators Grants