| Full text | |
| Author(s): Show less - |
Tizioto, Polyana C.
[1, 2]
;
Taylor, Jeremy F.
[2]
;
Decker, Jared E.
[2]
;
Gromboni, Caio F.
[3]
;
Mudadu, Mauricio A.
[4]
;
Schnabel, Robert D.
[2]
;
Coutinho, Luiz L.
[5]
;
Mourao, Gerson B.
[5]
;
Oliveira, Priscila S. N.
[1]
;
Souza, Marcela M.
[1]
;
Reecy, James M.
[6]
;
Nassu, Renata T.
[4]
;
Bressani, Flavia A.
[4]
;
Tholon, Patricia
[4]
;
Sonstegard, Tad S.
[7]
;
Alencar, Mauricio M.
[4]
;
Tullio, Rymer R.
[4]
;
Nogueira, Ana R. A.
[4]
;
Regitano, Luciana C. A.
[4]
Total Authors: 19
|
| Affiliation: | [1] Univ Fed Sao Carlos, Dept Genet & Evolut, BR-13560 Sao Carlos, SP - Brazil
[2] Univ Missouri, Div Anim Sci, Columbia, MO - USA
[3] Bahia Sci & Technol, Fed Inst Educ, Valenca, BA - Brazil
[4] Embrapa Southeast Livestock, Sao Carlos, SP - Brazil
[5] Univ Sao Paulo, Dept Anim Sci, ESALQ, Piracicaba, SP - Brazil
[6] Iowa State Univ, Dept Anim Sci, Ames, IA - USA
[7] USDA ARS, Beltsville, MD - USA
Total Affiliations: 7
|
| Document type: | Journal article |
| Source: | GENETICS SELECTION EVOLUTION; v. 47, MAR 11 2015. |
| Web of Science Citations: | 10 |
| Abstract | |
Background: Beef cattle require dietary minerals for optimal health, production and reproduction. Concentrations of minerals in tissues are at least partly genetically determined. Mapping genomic regions that affect the mineral content of bovine longissimus dorsi muscle can contribute to the identification of genes that control mineral balance, transportation, absorption and excretion and that could be associated to metabolic disorders. Methods: We applied a genome-wide association strategy and genotyped 373 Nelore steers from 34 half-sib families with the Illumina BovineHD BeadChip. Genome-wide association analysis was performed for mineral content of longissimus dorsi muscle using a Bayesian approach implemented in the GenSel software. Results: Muscle mineral content in Bos indicus cattle was moderately heritable, with estimates ranging from 0.29 to 0.36. Our results suggest that variation in mineral content is influenced by numerous small-effect QTL (quantitative trait loci) but a large-effect QTL that explained 6.5% of the additive genetic variance in iron content was detected at 72 Mb on bovine chromosome 12. Most of the candidate genes present in the QTL regions for mineral content were involved in signal transduction, signaling pathways via integral (also called intrinsic) membrane proteins, transcription regulation or metal ion binding. Conclusions: This study identified QTL and candidate genes that affect the mineral content of skeletal muscle. Our findings provide the first step towards understanding the molecular basis of mineral balance in bovine muscle and can also serve as a basis for the study of mineral balance in other organisms. (AU) | |
| FAPESP's process: | 10/06515-4 - Prospection and validation of SNPs in candidate genes for meat tenderness in reference families of Nellore breed |
| Grantee: | Polyana Cristine Tizioto |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 12/01502-7 - Transcriptional profile comparisons between infected and uninfected target tissues related to bovine respiratory disease |
| Grantee: | Polyana Cristine Tizioto |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |