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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Capacitive DNA Detection Driven by Electronic Charge Fluctuations in a Graphene Nanopore

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Author(s):
Feliciano, Gustavo T. [1, 2] ; Sanz-Navarro, Carlos [3] ; Coutinho-Neto, Mauricio Domingues [1] ; Ordejon, Pablo [3, 4] ; Scheicher, Ralph H. [5] ; Rocha, Alexandre Reily [6]
Total Authors: 6
Affiliation:
[1] Univ Fed ABC, Ctr Ciencias Nat & Humanas, BR-09210580 Santo Andre, SP - Brazil
[2] Univ Estadual Paulista, UNESP, Inst Quim, Dept Quim Fis, BR-14800060 Araraquara, SP - Brazil
[3] Inst Catala Nanociencia & Nanotecnol, ICN2, Barcelona 08193 - Spain
[4] CSIC, Barcelona 08193 - Spain
[5] Uppsala Univ, Div Mat Theory, Dept Phys & Astron, SE-75120 Uppsala - Sweden
[6] Univ Estadual Paulista, UNESP, Inst Fis Teor, BR-01140170 Sao Paulo, SP - Brazil
Total Affiliations: 6
Document type: Journal article
Source: PHYSICAL REVIEW APPLIED; v. 3, n. 3 MAR 9 2015.
Web of Science Citations: 29
Abstract

The advent of parallelized automated methods for rapid whole-genome analysis has led to an exponential drop in costs, thus greatly accelerating biomedical research and discovery. Third-generation sequencing techniques, which would utilize the characteristic electrical conductance of the four different nucleotides, could facilitate longer base read lengths and an even lower price per genome. In this work, we propose and apply a quantum-classical hybrid methodology to quantitatively determine the influence of the solvent on the dynamics of DNA and the resulting electron transport properties of a prototypic sequencing device utilizing a graphene nanopore through which the nucleic-acid chain is threaded. Our results show that charge fluctuations in the nucleotides are responsible for characteristic conductance modulations in this system, which can be regarded as a field-effect transistor tuned by the dynamic aqueous environment. (AU)

FAPESP's process: 13/02112-0 - Hibrid QM/MM methods applied to electronic transport simulations of graphene: applications to DNA sequencing and protein detection
Grantee:Alexandre Reily Rocha
Support type: Regular Research Grants