| Full text | |
| Author(s): |
Dropa, Milena
[1]
;
Ghiglione, Barbara
[2]
;
Matte, Maria Helena
[1]
;
Balsalobre, Livia Carminato
[1]
;
Lincopan, Nilton
[3]
;
Matte, Glavur Rogerio
[1]
;
Gutkind, Gabriel
[2]
;
Power, Pablo
[2]
Total Authors: 8
|
| Affiliation: | [1] Univ Sao Paulo, Sch Publ Hlth, Sao Paulo - Brazil
[2] Univ Buenos Aires, Sch Pharm & Biochem, Buenos Aires, DF - Argentina
[3] Univ Sao Paulo, Inst Biomed Sci, Sao Paulo - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | Antimicrobial Agents and Chemotherapy; v. 59, n. 3, p. 1815-1817, MAR 2015. |
| Web of Science Citations: | 3 |
| Abstract | |
CTX-M-131 is a natural Asp240Gly variant from the CTX-M-2 group detected in a Providencia rettgeri clinical strain from Brazil. Molecular analysis showed that bla(CTX-M-131) was inserted in a complex class 1 integron harbored by a 112-kb plasmid, which has not been previously described as a platform for CTX-M-encoding genes with the Asp240Gly mutation. Steady-state kinetic parameters showed that the enzyme has a typical cefotaximase catalytic profile and an enhanced activity against ceftazidime. (AU) | |
| FAPESP's process: | 13/07943-8 - Biochemical Characterization of New Variants of Extended-Spectrum ²-lactamases (ESBL) Identified at São Paulo, SP, Brasil. |
| Grantee: | Milena Dropa |
| Support Opportunities: | Scholarships abroad - Research |
| FAPESP's process: | 10/12841-1 - Identification and localization of ²-lactam and tetracycline resistance genes, in clinical and environmental Enterobacteriaceae and Aeromonas hydrophila strains. |
| Grantee: | Maria Helena Matte |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 08/08312-3 - Molecular identification of ESBL-encoding resistance genes, detected in Enterobacteriaceae clinical strains related to hospital infections. |
| Grantee: | Maria Helena Matte |
| Support Opportunities: | Regular Research Grants |