Influence of Microelement Concentration on the Intensity of Alcohol Withdrawal Syndrome

Author(s)

Prior, Pedro Luis ^[1] ; Vaz, Marta Jezierski ^[2] ; Ramos, Anna Carolina ^[1] ; Fernandes Galduroz, Jose Carlos ^[1]

Affiliation

^[1] Univ Fed Sao Paulo UNIFESP, Dept Psychobiol, Sao Paulo - Brazil

^[2] Ctr Referencia Tratamento Alcool Tabaco & Outras, Sao Paulo - Brazil

• Document type: Journal article
• Source: ALCOHOL AND ALCOHOLISM; v. 50, n. 2, p. 152-156, MAR-APR 2015.
• Web of Science Citations: 2

Abstract

Aims: To establish a nutritional and constitutional profile concerning the micronutrient plasma concentration of patients who suffer from AWS. Method: Observational case control study to determine whether patients who exhibited symptoms of AWS (N = 60) had micronutrient plasmatic concentration deficiencies when compared with healthy controls (N = 34). Results: There were statistically significant differences between the concentrations of nutrients that are correlated with glutamate hyperactivity (zinc, magnesium and folate/vitamin B12/homocysteine). Conclusion: Evidence from literature and our experiment suggests that brain activity, especially the glutamatergic system, might be directly involved in micronutrient concentrations. Therefore, their supplementation to the AWS patient might improve symptom evolution. (AU)

• FAPESP's process: 12/06731-4 - Studying the effects of administration of polyunsaturated fatty acids (PUFAs) of omega-3 series in nicotine dependence
• Grantee: José Carlos Fernandes Galduroz
• Support Opportunities: Regular Research Grants