A MATHEMATICAL MODEL TO ASSESS THE IMMUNE RESPONSE AGAINST TRYPANOSOMA CRUZI INFECTION

Yang, Hyun Mo

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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A MATHEMATICAL MODEL TO ASSESS THE IMMUNE RESPONSE AGAINST TRYPANOSOMA CRUZI INFECTION

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Author(s):	Yang, Hyun Mo ^[1] Total Authors: 1
Affiliation:	^[1] UNICAMP IMECC DMA, BR-13083859 Campinas, SP - Brazil Total Affiliations: 1
Document type:	Journal article
Source:	JOURNAL OF BIOLOGICAL SYSTEMS; v. 23, n. 1 MAR 2015.
Web of Science Citations:	1
Abstract
A mathematical model is developed to assess Immoral and cellular 411 MU. le responses against Trypanosoma cruzi infection. Analysis of the model shows a unique non-trivial equilibrium, which is locally asymptotically stable, except in the case of a strong cellular response. When the proliferation of the activated CD8 T cells is increased, this equilibrium becomes unstable and a limit cycle appears. However, this behavior can he avoided by increasing the action of the humoral response. Therefore, unbalanced humoral and cellular responses can be responsible for long asymptomatic period, and the control of Trypanosoma Cruzi infection is a consequence of well coordinated action of both humoral and cellular responses. (AU)

FAPESP's process:	09/15098-0 - Assessing control of epidemics using mathematical and computer models
Grantee:	Hyun Mo Yang
Support Opportunities:	Research Projects - Thematic Grants

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