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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Independent purinergic mechanisms of central and peripheral chemoreception in the rostral ventrolateral medulla

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Author(s):
Moreira, Thiago S. [1] ; Wenker, Ian C. [2] ; Sobrinho, Cleyton R. [1] ; Barna, Barbara F. [1] ; Takakura, Ana C. [3] ; Mulkey, Daniel K. [4]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Dept Physiol & Biophys, BR-05508 Sao Paulo, SP - Brazil
[2] Univ Virginia, Dept Pharmacol, Charlottesville, VA 22908 - USA
[3] Univ Sao Paulo, Dept Pharmacol, BR-05508 Sao Paulo, SP - Brazil
[4] Univ Connecticut, Dept Physiol & Neurobiol, Storrs, CT 06269 - USA
Total Affiliations: 4
Document type: Journal article
Source: JOURNAL OF PHYSIOLOGY-LONDON; v. 593, n. 5, p. 1067-1074, MAR 1 2015.
Web of Science Citations: 6
Abstract

The rostral ventrolateral medulla oblongata (RVLM) contains two functionally distinct types of neurons that control and orchestrate cardiovascular and respiratory responses to hypoxia and hypercapnia. One group is composed of the central chemoreceptor neurons of the retrotrapezoid nucleus, which provides a CO2/H+-dependent drive to breathe and serves as an integration centre and a point of convergence of chemosensory information from other central and peripheral sites, including the carotid bodies. The second cluster of RVLM cells forms a population of neurons belonging to the C1 catecholaminergic group that controls sympathetic vasomotor tone in resting conditions and in conditions of hypoxia and hypercapnia. Recent evidence suggests that ATP-mediated purinergic signalling at the level of the RVLM co-ordinates cardiovascular and respiratory responses triggered by hypoxia and hypercapnia by activating retrotrapezoid nucleus and C1 neurons, respectively. The role of ATP-mediated signalling in the RVLM mechanisms of cardiovascular and respiratory activities is the main subject of this short review. (AU)

FAPESP's process: 11/13462-7 - The interaction between retrotrapezoid nucleus astrocytes and neurons on respiratory responses promoted by central chemoreflex activation
Grantee:Cleyton Roberto Sobrinho
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 10/09776-3 - Neural mechanisms involved in expiratory rhythm generator: possible involvement of the retrotrapezoid nucleus and the parafacial region
Grantee:Ana Carolina Takakura Moreira
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 13/10573-8 - Ventral surface chemoreceptor neuronal mechanisms
Grantee:Thiago dos Santos Moreira
Support Opportunities: Regular Research Grants
FAPESP's process: 12/10337-0 - Neural mechanisms involved in purinergic signaling in the control of central and peripheral chemosensitivity
Grantee:Bárbara Falquetto
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 09/54888-7 - Neural mechanisms involved on chemoreception
Grantee:Eduardo Colombari
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 13/02350-9 - Regulation of ventral surface CO2/H+-sensitive neurons by purinergic signalling in newborn rats
Grantee:Cleyton Roberto Sobrinho
Support Opportunities: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 14/04866-5 - Role of P2Y1 receptors within the C1 neurons controlling breathing and blood pressure
Grantee:Bárbara Falquetto
Support Opportunities: Scholarships abroad - Research Internship - Doctorate