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Neural mechanisms involved on chemoreception

Abstract

Respiration is a physiological process essential to life. The neural circuit that generates the respiratory rhythm and produces the orderly activation of the various respiratory motor outflows (henceforth called central pattern generator, CPG) it is organized at the braistem level. Brain CO2 is almost certainly detected via changes in pH but how pH is detected, where pH is detected and how brain acidification stimulates breathing (the central chemoreflex) are still controversial. A relatively recent theory postulates that central respiratory chemoreception results from the cumulative effect of pH on the CPG itself and many of its tonic drives. The strongest evidence in favor of the specialized chemoreceptor theory came recently from the most ancient approach to neuroscience, namely human pathophysiology. The congenital central hypoventilation syndrome (CCHS), a rare developmental disease caused by mutations of the transcription factor Phox2b is characterized by a virtually complete loss of the central respiratory chemoreception, typically complete sleep apnea but usually maintained breathing during waking and exercise. At this moment, we don't know the real participation of the Phox2b neurons of the RTN in the control of breathing in an animal model without anesthesia. However, in this thematic project our main objective is to understand the cardio-respiratory responses elicted by hypercapnia in conscious rats with specific lesion of the Phox2b neurons in the RTN. To study the cardio-respiratory effects of hypercapnia we will use different experimental methods, which includes pharmacological, eletrophysiological and imunohistochemistry approaches. (AU)

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VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (20)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
TOTOLA, L. T.; ALVES, T. B.; TAKAKURA, A. C.; FERREIRA-NETO, H. C.; ANTUNES, V. R.; MENANI, J. V.; COLOMBARI, E.; MOREIRA, T. S.. COMMISSURAL NUCLEUS OF THE SOLITARY TRACT REGULATES THE ANTIHYPERTENSIVE EFFECTS ELICITED BY MOXONIDINE. Neuroscience, v. 250, p. 80-91, . (11/11934-9, 09/54888-7, 10/09776-3, 10/19336-0, 11/50770-1)
SILVA, JOSIANE N.; LUCENA, ELVIS V.; SILVA, TALITA M.; DAMASCENO, ROSELIA S.; TAKAKURA, ANA C.; MOREIRA, THIAGO S.. INHIBITION OF THE PONTINE KOLLIKER-FUSE NUCLEUS REDUCES GENIOGLOSSAL ACTIVITY ELICITED BY STIMULATION OF THE RETROTRAPEZOID CHEMORECEPTOR NEURONS. Neuroscience, v. 328, p. 9-21, . (09/54888-7, 10/09776-3, 13/00401-5, 10/15692-7, 13/10573-8, 12/16166-2, 12/03568-5)
ZOCCAL, DANIEL B.; FURUYA, WERNER I.; BASSI, MIRIAN; COLOMBARI, DEBORA S. A.; COLOMBARI, EDUARDO. The nucleus of the solitary tract and the coordination of respiratory and sympathetic activities. FRONTIERS IN PHYSIOLOGY, v. 5, . (09/54888-7, 11/20040-1)
FURUYA, WERNER I.; BASSI, MIRIAN; MENANI, JOSE V.; COLOMBARI, EDUARDO; ZOCCAL, DANIEL B.; COLOMBARI, DEBORA S. A.. Differential modulation of sympathetic and respiratory activities by cholinergic mechanisms in the nucleus of the solitary tract in rats. Experimental Physiology, v. 99, n. 5, p. 743-758, . (10/17218-0, 09/54888-7, 11/20040-1)
LEMES, EDUARDO V.; COLOMBARI, EDUARDO; ZOCCAL, DANIEL B.. Generation of active expiration by serotoninergic mechanisms of the ventral medulla of rats. Journal of Applied Physiology, v. 121, n. 5, p. 1135-1144, . (13/17251-6, 14/06976-2, 09/54888-7)
BARNA, B. F.; TAKAKURA, A. C.; MULKEY, D. K.; MOREIRA, T. S.. Purinergic receptor blockade in the retrotrapezoid nucleus attenuates the respiratory chemoreflexes in awake rats. ACTA PHYSIOLOGICA, v. 217, n. 1, p. 80-93, . (12/10337-0, 09/54888-7, 10/09776-3, 13/10573-8)
FURUYA, WERNER I.; COLOMBARI, EDUARDO; FERGUSON, ALASTAIR V.; COLOMBARI, DEBORA S. A.. Effects of acetylcholine and cholinergic antagonists on the activity of nucleus of the solitary tract neurons. Brain Research, v. 1659, p. 136-141, . (10/17218-0, 11/20040-1, 09/54888-7, 12/05844-0)
MOREIRA, THIAGO S.; WENKER, IAN C.; SOBRINHO, CLEYTON R.; BARNA, BARBARA F.; TAKAKURA, ANA C.; MULKEY, DANIEL K.. Independent purinergic mechanisms of central and peripheral chemoreception in the rostral ventrolateral medulla. JOURNAL OF PHYSIOLOGY-LONDON, v. 593, n. 5, p. 1067-1074, . (12/10337-0, 09/54888-7, 10/09776-3, 14/04866-5, 11/13462-7, 13/10573-8, 13/02350-9)
ZOCCAL, DANIEL B.; SILVA, JOSIANE N.; BARNETT, WILLIAM H.; LEMES, EDUARDO V.; FALQUETTO, BARBARA; COLOMBARI, EDUARDO; MOLKOV, YAROSLAV I.; MOREIRA, THIAGO S.; TAKAKURA, ANA C.. Interaction between the retrotrapezoid nucleus and the parafacial respiratory group to regulate active expiration and sympathetic activity in rats. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, v. 315, n. 5, p. L891-L909, . (09/54888-7, 16/23281-3, 15/23376-1, 16/22069-0, 14/22406-1, 13/17251-6)
TAKAKURA, ANA C.; MOREIRA, THIAGO S.; DE PAULA, PATRICIA M.; MENANI, JOSE V.; COLOMBARI, EDUARDO. Control of breathing and blood pressure by parafacial neurons in conscious rats. Experimental Physiology, v. 98, n. 1, p. 304-315, . (09/54888-7, 10/09776-3, 10/19336-0)
LEMES, E. V.; AIKO, S.; ORBEM, C. B.; FORMENTIN, C.; BASSI, M.; COLOMBARI, E.; ZOCCAL, D. B.. Long-term facilitation of expiratory and sympathetic activities following acute intermittent hypoxia in rats. ACTA PHYSIOLOGICA, v. 217, n. 3, p. 254-266, . (13/17251-6, 14/06976-2, 09/54888-7)
DE BRITO ALVES, JOSE L.; NOGUEIRA, VIVIANE O.; CAVALCANTI NETO, MARINALDO P.; LEOPOLDINO, ANDREIA M.; CURTI, CARLOS; COLOMBARI, DEBORA S. A.; COLOMBARI, EDUARDO; WANDERLEY, ALMIR G.; LEANDRO, CAROL G.; ZOCCAL, DANIEL B.; et al. Maternal Protein Restriction Increases Respiratory and Sympathetic Activities and Sensitizes Peripheral Chemoreflex in Male Rat Offspring. Journal of Nutrition, v. 145, n. 5, p. 907-914, . (09/54888-7, 11/20040-1)
SOBRINHO, CLEYTON R.; KUO, FU-SHAN; BARNA, BARBARA F.; MOREIRA, THIAGO S.; MULKEY, DANIEL K.. Cholinergic control of ventral surface chemoreceptors involves Gq/inositol 1,4,5-trisphosphate-mediated inhibition of KCNQ channels. JOURNAL OF PHYSIOLOGY-LONDON, v. 594, n. 2, p. 407-419, . (09/54888-7, 13/10573-8)
ALVES, THALES B.; TOTOLA, LEONARDO T.; TAKAKURA, ANA C.; COLOMBARI, EDUARDO; MOREIRA, THIAGO S.. GABA mechanisms of the nucleus of the solitary tract regulates the cardiovascular and sympathetic effects of moxonidine. AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, v. 194, p. 1-7, . (11/11934-9, 09/54888-7, 14/22406-1, 13/10573-8)
MOREIRA, THIAGO S.; TAKAKURA, ANA C.; CZEISLER, CATHERINE; OTERO, JOSE J.. Respiratory and autonomic dysfunction in congenital central hypoventilation syndrome. Journal of Neurophysiology, v. 116, n. 2, p. 742-752, . (09/54888-7, 14/22406-1, 13/10573-8)
BASSI, M.; NAKAMURA, N. B.; FURUYA, W. I.; COLOMBARI, D. S. A.; MENANI, J. V.; DO CARMO, J. M.; DA SILVA, A. A.; HALL, J. E.; COLOMBARI, E.. Activation of the brain melanocortin system is required for leptin-induced modulation of chemorespiratory function. ACTA PHYSIOLOGICA, v. 213, n. 4, p. 893-901, . (09/54888-7)
HAWKINS, VIRGINIA E.; HAWRVLUK, JOANNA M.; TAKAKURA, ANA C.; TZINGOUNIS, ANASTASIOS V.; MOREIRA, THIAGO S.; MULKEY, DANIEL K.. HCN channels contribute to serotonergic modulation of ventral surface chemosensitive neurons and respiratory activity. Journal of Neurophysiology, v. 113, n. 4, p. 1195-1205, . (09/54888-7, 10/09776-3, 13/10573-8)
BASSI, M.; FURUYA, W. I.; ZOCCAL, D. B.; MENANI, J. V.; COLOMBARI, E.; HALL, J. E.; DA SILVA, A. A.; DO CARMO, J. M.; COLOMBARI, D. S. A.. Control of respiratory and cardiovascular functions by leptin. Life Sciences, v. 125, p. 25-31, . (09/54888-7)
MULKEY, DANIEL K.; HAWKINS, VIRGINIA E.; HAWRYLUK, JOANNA M.; TAKAKURA, ANA C.; MOREIRA, THIAGO S.; TZINGOUNIS, ANASTASIOS V.. Molecular underpinnings of ventral surface chemoreceptor function: focus on KCNQ channels. JOURNAL OF PHYSIOLOGY-LONDON, v. 593, n. 5, p. 1075-1081, . (09/54888-7, 10/09776-3, 13/10573-8)
ZOCCAL, DANIEL B.. Peripheral chemoreceptors and cardiorespiratory coupling: a link to sympatho-excitation. Experimental Physiology, v. 100, n. 2, p. 143-148, . (09/54888-7, 13/06077-5)

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