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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Peripheral chemoreceptors and cardiorespiratory coupling: a link to sympatho-excitation

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Zoccal, Daniel B. [1]
Total Authors: 1
[1] Sao Paulo State Univ UNESP, Sch Dent Araraquara, Dept Physiol & Pathol, BR-14801903 Araraquara, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Experimental Physiology; v. 100, n. 2, p. 143-148, FEB 1 2015.
Web of Science Citations: 9

New Findings What is the topic of this review? Chronic intermittent hypoxia (CIH), as observed in patients with obstructive sleep apnoea, is associated with the development of sympathetically mediated arterial hypertension. Nevertheless, the mechanisms underpinning the augmented sympathetic outflow in CIH still remain under investigation. What advances does it highlight? In this report, I present experimental evidence supporting the hypothesis that changes in the function of the respiratory network and coupling with the sympathetic nervous system may be considered as a novel and relevant mechanism for the increase in baseline sympathetic outflow in animals submitted to CIH. Chronic intermittent hypoxia (CIH) has been identified as a relevant risk factor for the development of enhanced sympathetic outflow and arterial hypertension. Several studies have highlighted the importance of peripheral chemoreceptors for the cardiovascular changes elicited by CIH. However, the effects of CIH on the central mechanisms regulating sympathetic outflow are not fully elucidated. Our research group has explored the hypothesis that the enhanced sympathetic drive following CIH exposure is, at least in part, dependent on alterations in the respiratory network and its interaction with the sympathetic nervous system. In this report, I discuss the changes in the discharge profile of baseline sympathetic activity in rats exposed to CIH, their association with the generation of active expiration and the interactions between expiratory and sympathetic neurones after CIH conditioning. Together, these findings are consistent with the theory that mechanisms of central respiratory-sympathetic coupling are a novel factor in the development of neurogenic hypertension. (AU)

FAPESP's process: 13/06077-5 - Changes in the neural networks involved with the generation and control of sympathetic and respiratory activities in different experimental models of hypoxia
Grantee:Benedito Honorio Machado
Support type: Research Projects - Thematic Grants
FAPESP's process: 09/54888-7 - Neural mechanisms involved on chemoreception
Grantee:Eduardo Colombari
Support type: Research Projects - Thematic Grants